Francisco de Aguilar may refer to:
- Francisco de Aguilar (conquistador) (1479–1571?), Spanish conquistador and later Dominican friar, participant in the conquest of the Aztec Empire
- Francisco de Aguilar (politician) (fl. 1850s), 19th century Honduran politician and one-time interim president (1855–56)
This disambiguation page lists articles about people with the same name.
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