Francis Gregory (1789–1866) was a U.S. naval officer.
Frank or Francis Gregory may also refer to:
- Francis Gregory (bishop) (1848–1927), British Anglican colonial bishop
- Francis Gregory (sportsman) (1904–?), Cornish and professional wrestler, and rugby union and rugby league footballer
- Francis Thomas Gregory (1821–1888), English-born Australian explorer and politician
- Frank Gregory (baseball) (1888–1955), MLB player
- Francis Gregory (divine) (c. 1625–1707), English divine and schoolmaster
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