Flye may refer to:

  • Don Flye (1933–2013), American tennis player
  • Edwin Flye (1817–1886), American politician, merchant, banker, bank president, and shipbuilder
  • Father James Harold Flye, Episcopal priest, history teacher, and lifelong friend and mentor of James Agee
  • Tom Flye, drummer for Lothar and the Hand People, an American 1960s psychedelic rock band
  • Flye or Fly (exercise), a strength training exercise