Flight 251 may refer to:
- Faucett Flight 251, a Boeing 707 that crashed on 29 February 1996 in Arequipa, Peru, killing all 129 people on board
- Petropavlovsk-Kamchatsky Air Flight 251 (2012), an Antonov An-28 that crashed on 12 September 2012 in Palana, Russia, killing 10 of the 14 people on board
- Petropavlovsk-Kamchatsky Air Flight 251 (2021), an Antonov An-26 that crashed on 6 July 2021 in Palana, Russia, killing all 28 people on board
This disambiguation page lists articles associated with the title Flight 251.
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