Flight 121 may refer to:
- Mohawk Airlines Flight 121, which crashed on 2 July 1963 during takeoff in Rochester, New York
- Pan Am Flight 121, which suffered an engine failure and crashed on 18 June 1947 in Mayadine, Syria
- South Pacific Airlines Flight 121, a fictional flight in Snakes on a Plane
This disambiguation page lists articles associated with the title Flight 121.
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