FERM and PDZ domain containing 4 is a protein that in humans is encoded by the FRMPD4 gene. [5]

FRMPD4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFRMPD4, PDZD10, PDZK10, FERM and PDZ domain containing 4, MRX104
External IDsOMIM: 300838; MGI: 3042378; HomoloGene: 45843; GeneCards: FRMPD4; OMA:FRMPD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014728

RefSeq (protein)
Location (UCSC)Chr X: 12.14 – 12.72 MbChr X: 166.25 – 167.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169933Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049176Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: FERM and PDZ domain containing 4". Retrieved 2016-10-01.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.