FOXF1

Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene.

FOXF1
Identifiers
Aliases	FOXF1, ACDMPV, FKHL5, FREAC1, forkhead box F1
External IDs	OMIM: 601089; MGI: 1347470; HomoloGene: 1114; GeneCards: FOXF1; OMA:FOXF1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q24.1 Start 86,510,527 bp End 86,515,422 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 E1|8 70.31 cM Start 121,811,125 bp End 121,814,883 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon gastric mucosa right lung lower lobe of lung urinary bladder mucosa of urinary bladder buccal mucosa cell upper lobe of lung upper lobe of left lung pylorus Top expressed in right lung lobe left lung lobe migratory enteric neural crest cell molar somatopleuric mesenchyme lamina propria of urethra mandibular prominence urinary bladder extraembryonic membrane yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus Biological process somitogenesis regulation of smooth muscle cell differentiation renal system development ureter development regulation of transcription, DNA-templated lung morphogenesis embryonic foregut morphogenesis lung development positive regulation of cell migration endocardial cushion development cellular response to organic cyclic compound extracellular matrix organization cardiac left ventricle morphogenesis in utero embryonic development negative regulation of transcription by RNA polymerase II negative regulation of mast cell degranulation smooth muscle cell differentiation morphogenesis of a branching structure venous blood vessel development cellular response to cytokine stimulus right lung morphogenesis transcription, DNA-templated vasculogenesis positive regulation of transcription, DNA-templated respiratory tube development heart development determination of left/right symmetry establishment of epithelial cell apical/basal polarity blood vessel development embryonic ectodermal digestive tract morphogenesis positive regulation of mesenchymal cell proliferation embryonic digestive tract morphogenesis animal organ morphogenesis pancreas development detection of wounding mesenchyme migration smoothened signaling pathway lateral mesodermal cell differentiation lung alveolus development digestive tract development lung vasculature development mesoderm development epithelial tube branching involved in lung morphogenesis negative regulation of inflammatory response lung lobe morphogenesis ductus arteriosus closure embryonic digestive tract development positive regulation of transcription by RNA polymerase II epithelial cell differentiation involved in mammary gland alveolus development midgut development positive regulation of cell-substrate adhesion transcription by RNA polymerase II cell differentiation cell-cell adhesion trachea development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2294 15227 Ensembl ENSG00000103241 ENSMUSG00000042812 UniProt Q12946 Q61080 RefSeq (mRNA) NM_001451 NM_010426 RefSeq (protein) NP_001442 NP_034556 Location (UCSC) Chr 16: 86.51 – 86.52 Mb Chr 8: 121.81 – 121.81 Mb PubMed search
Wikidata
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Function

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal tract.

Further reading

• Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Jun 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics. 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.
• Hellqvist M, Mahlapuu M, Samuelsson L, Enerbäck S, Carlsson P (Feb 1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2". The Journal of Biological Chemistry. 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802.
• Hellqvist M, Mahlapuu M, Blixt A, Enerbäck S, Carlsson P (Sep 1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB". The Journal of Biological Chemistry. 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567.
• Mahlapuu M, Pelto-Huikko M, Aitola M, Enerbäck S, Carlsson P (Oct 1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces". Developmental Biology. 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171.
• Coon DR, Roberts DJ, Loscertales M, Kradin R (Apr 2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia". Experimental and Molecular Pathology. 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649.
• Lomenick JP, Hubert MA, Handwerger S (Nov 2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression". American Journal of Physiology. Endocrinology and Metabolism. 291 (5): E947-51. doi:10.1152/ajpendo.00128.2006. PMID 16772323.

External links

• FOXF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.