Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene.[5] The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.
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| Aliases | FANCD2OS, C3orf24, FANCD2 opposite strand | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1918229 HomoloGene: 45456 GeneCards: FANCD2OS | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene edit
The gene is encoded on Chromosome 3 (human) at p25.3 on the minus strand from 10081320-10108339nt. The primary transcript is 1105nt which codes for a protein of 177 amino acid in length.[6] The gene on the strand complementary to FANCD2 located 5' from CYCSP11 and 3’ from BRK1 and VHL genes.[5]
mRNA edit
There are six alternatively spliced transcripts with differences in the 5' and 3' ends as well changes in exon usage.[7] The most common isoform is 1105 bp.[8]
Promoter Region edit
The promoter region predicted by the Genomatix El Dorado algorithm spans from 10108742-10108009 bp. Promoters are associated with a wide variety of tissues including B-lymphocytes, germ cells, muscle, neurons & prostate.
Regulatory edit
Secondary structure of the 5’ UTR sequence conserved between humans and gibbon contain sequence recognized by to RBMX, Ras & Rab proteins. The sequence for the secondary structure of the 3’ UTR are recognized by EIF4B and RBMX.
Expression edit
FANCD2OS is moderately expressed in the human brain, placenta and testes.[9]
Evolutionary History edit
Protein sequence edit
The protein from the longest transcript is 177AA in length with a mass of 20188.59kD. The protein consists of a domain of unknown function from the DUF4563 superfamily.[10]
Orthologs edit
Orthologs of FANCD2OS exist throughout mammals, reptiles, birds and in the cartilaginous fish Australian ghostshark.[11] The protein sequence undergoes mutation at a rate similar to the blood protein fibrinogen.
| Species | Common name | NCBI accession | Identity | similarity | E-value |
|---|---|---|---|---|---|
| Pongo abelii | Sumatran orangutan | XP_003776240.1 | 98.9 | 99.4 | 1.21E-133 |
| Cricetulus griseus | Chinese hamster | XP_003511850.1 | 73.6 | 80.9 | 1.56E-95 |
| Ovis aries | Sheep | XP_004018322.1 | 97.2 | 98.3 | 6.79E-131 |
| Leptonychotes weddellii | Weddell seal | XP_006739055.1 | 96.6 | 98.3 | 5.13E-130 |
| Condylura cristata | Star-nosed mole | XP_004692437.1 | 91.0 | 95.5 | 3.01E-123 |
| Orcinus orca | Killer whale | XP_004286877.2 | 88.1 | 92.3 | 1.05E-90 |
| Trichechus manatus latirostris | Florida manatee | XP_004368376.1 | 96.6 | 98.9 | 9.95E-131 |
| Alligator mississippiensis | American alligator | XP_014457972.1 | 69.3 | 88.6 | 1.40E-48 |
| Chrysemys picta bellii | Painted turtle | XP_005307285.1 | 58.3 | 75 | 2.18E-78 |
| Gekko japonicus | Schlegel's Japanese gecko | XP_015261231.1 | 56.5 | 72.3 | 4.39E-74 |
| Thamnophis sirtalis | Common garter snake | XP_013914711.1 | 55.9 | 69.5 | 2.75E-69 |
| Xenopus laevis | African clawed frog | NP_001088778.1 | 55.4 | 71.2 | 1.98E-68 |
| Xenopus tropicalis | Western clawed frog | NP_001090717.1 | 52 | 71.2 | 3.57E-65 |
| Callorhinchus milii | Australian ghostshark | XP_007888744.1 | 39.9 | 56.8 | 5.67E-43 |
Paralogs edit
FANCD2OS has no known paralogs in Homo sapiens.
References edit
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163705 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033963 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene - FANCD2OS FANCD2 opposite strand Homo sapiens". Retrieved 6 February 2016.
- ^ a b "FANCD2 opposite strand protein". NCBI. Retrieved 2 May 2016.
- ^ a b "AceView C3orf24". NCBI. Retrieved 2 May 2016.
- ^ "Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant 1, mRNA". NCBI Nucleotide. NCBI. Retrieved 19 April 2016.
- ^ a b "NCBI - GDS592 / gnf1m17159_at / Fancd2os". NCBI. Retrieved 15 Mar 2016.
- ^ a b "Conserved Protein Domain Family DUF4563". NCBI. Retrieved 2 May 2016.
- ^ a b "Homologene: FANCD2OS". Retrieved 6 February 2016.