Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.[5]

F2RL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesF2RL3, PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
External IDsOMIM: 602779; MGI: 1298207; HomoloGene: 36148; GeneCards: F2RL3; OMA:F2RL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003950

NM_007975

RefSeq (protein)

NP_003941

NP_032001

Location (UCSC)Chr 19: 16.89 – 16.89 MbChr 8: 73.49 – 73.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127533Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050147Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.