F-box protein 16 is a protein that in humans is encoded by the FBXO16 gene.[5]
| FBXO16 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | FBXO16, FBX16, F-box protein 16 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608519 MGI: 1354706 HomoloGene: 9273 GeneCards: FBXO16 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function edit
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene.
References edit
- ^ a b c GRCh38: Ensembl release 89: ENSG00000214050 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034532 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: F-box protein 16". Retrieved 2016-09-13.
Further reading edit
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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