EXTL3

EXTL3
Identifiers
Aliases	EXTL3, BOTV, EXTL1L, EXTR1, REGR, RPR, exostosin like glycosyltransferase 3, ISDNA
External IDs	OMIM: 605744 MGI: 1860765 HomoloGene: 1103 GeneCards: EXTL3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	28,756,561 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	65,387,304 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; islet of Langerhans; ; prefrontal cortex; ; gastric mucosa; ; frontal pole; ; Brodmann area 10; ; left ventricle; ; smooth muscle tissue; ; middle frontal gyrus;
	Top expressed in
	aortic valve; ; ascending aorta; ; internal carotid artery; ; external carotid artery; ; renal corpuscle; ; piriform cortex; ; entorhinal cortex; ; atrium; ; pineal gland; ; visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; metal ion binding; glycosyltransferase activity;
Cellular component	integral component of membrane; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus;
Biological process	positive regulation of cell growth; IRE1-mediated unfolded protein response; heparan sulfate proteoglycan biosynthetic process; protein glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	2137
	54616
	ENSG00000012232
	ENSMUSG00000021978
	O43909
	Q9WVL6; Q6P1H4
	NM_001440
	NM_018788; NM_001360385
	NP_001431
NP_061258; NP_001347314; NP_001391867; NP_001391868; NP_001391869;
	NP_001391870; NP_001391871; NP_001391872; NP_001391873; NP_001391874; NP_001391875
	Wikidata
View/Edit Human	View/Edit Mouse

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.^[5]^[6]^[7]^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000012232 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021978 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van Hul W, Wuyts W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Bossuyt P, Willems PJ (Apr 1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family". Genomics. 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.
^ Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
^ Mizuno K, Irie S, Sato TA (Mar 2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha". Cell Signal. 13 (2): 125–30. doi:10.1016/S0898-6568(00)00144-3. PMID 11257457.
^ "Entrez Gene: EXTL3 exostoses (multiple)-like 3".

Further reading edit

Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family". Biochem. Biophys. Res. Commun. 243 (1): 61–6. doi:10.1006/bbrc.1997.8062. PMID 9473480.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
McCormick C, Duncan G, Goutsos KT, Tufaro F (2000). "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. Bibcode:2000PNAS...97..668M. doi:10.1073/pnas.97.2.668. PMC 15388. PMID 10639137.
Kobayashi S, Akiyama T, Nata K, et al. (2000). "Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor". J. Biol. Chem. 275 (15): 10723–6. doi:10.1074/jbc.275.15.10723. PMID 10753861.
Kim BT, Kitagawa H, Tamura Ji J, et al. (2002). "Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation". J. Biol. Chem. 277 (16): 13659–65. doi:10.1074/jbc.M111630200. PMID 11832488.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bishnupuri KS, Luo Q, Korzenik JR, et al. (2007). "Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes". Cancer Biol. Ther. 5 (12): 1714–20. doi:10.4161/cbt.5.12.3469. PMID 17106246.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000012232 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021978 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9479495-5] Van Hul W, Wuyts W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Bossuyt P, Willems PJ (Apr 1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family". Genomics. 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.

[pmid9450183-6] Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.

[pmid11257457-7] Mizuno K, Irie S, Sato TA (Mar 2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha". Cell Signal. 13 (2): 125–30. doi:10.1016/S0898-6568(00)00144-3. PMID 11257457.

[entrez-8] "Entrez Gene: EXTL3 exostoses (multiple)-like 3".

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