Erlin-1 (Endoplasmic Reticulum lipid raft-associated 1) is a protein encoded by the ERLIN1gene in humans.[5][6][7]
ERLIN1 and its homolog ERLIN2 are ER-localized members of the stomatin/prohibition/flotillin/HflKC (SPFH) family of proteins. They form a complex that functions to scaffold lipids and proteins.[8]
ERLIN1 and ERLIN2 are predicted to assemble in a large ring-shaped hetero-oligomeric complex, likely formed by 24 subunits, similar to other members of the SPFH family.[9][10]
ERLIN1/2 are associated with cholesterol homeostasis. They interact with the SCAP–SREBP2–INSIG complex tightly under cholesterol repletion conditions, thus keeping this complex in the ER, where it is inactive. Silencing of ERLINs releases SREBP2 from the ER and allows it to travel to the Golgi, where it is processed and drives transcription of cholesterol synthesis genes. Activation of the SREBP2 pathway is as potent under ERLINs silencing as it is under cholesterol depletion conditions.[11]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Li N, Huang X, Zhao Z, Chen G, Zhang W, Cao X (Feb 2001). "Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells". Biochem Biophys Res Commun. 279 (2): 487–93. doi:10.1006/bbrc.2000.3935. PMID11118313.
^Browman, Duncan T.; Hoegg, Maja B.; Robbins, Stephen M. (August 2007). "The SPFH domain-containing proteins: more than lipid raft markers". Trends in Cell Biology. 17 (8): 394–402. doi:10.1016/j.tcb.2007.06.005.
^Yokoyama, Hideshi; Matsui, Ikuo (May 2023). "Higher‐order structure formation using refined monomer structures of lipid raft markers, Stomatin, Prohibitin, Flotillin, and HflK /C‐related proteins". FEBS Open Bio. 13 (5): 926–937. doi:10.1002/2211-5463.13593.
^Huber, Michael D.; Vesely, Paul W.; Datta, Kaustuv; Gerace, Larry (11 November 2013). "Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis". Journal of Cell Biology. 203 (3): 427–436. doi:10.1083/jcb.201305076.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
