ELF4

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.

ELF4
Identifiers
Aliases	ELF4, ELFR, MEF, E74 like ETS transcription factor 4, AIFBL2
External IDs	OMIM: 300775; MGI: 1928377; HomoloGene: 31036; GeneCards: ELF4; OMA:ELF4 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq26.1 Start 130,063,955 bp End 130,110,716 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A5 Start 47,499,923 bp End 47,552,009 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood mononuclear cell monocyte cartilage tissue germinal epithelium mucosa of transverse colon mucosa of ileum jejunal mucosa mucosa of sigmoid colon Top expressed in granulocyte ascending aorta aortic valve urethra male urethra tibiofemoral joint thymus genital tubercle lip tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component PML body nucleus nucleoplasm nuclear body Biological process natural killer cell proliferation positive regulation of transcription, DNA-templated NK T cell proliferation cell differentiation innate immune response regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2000 56501 Ensembl ENSG00000102034 ENSMUSG00000031103 UniProt Q99607 Q9Z2U4 RefSeq (mRNA) NM_001127197 NM_001421 NM_019680 NM_001381876 RefSeq (protein) NP_001120669 NP_001412 NP_062654 NP_001368805 Location (UCSC) Chr X: 130.06 – 130.11 Mb Chr X: 47.5 – 47.55 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD (April 2006). "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2". Molecular and Cellular Biology. 26 (8): 3114–23. doi:10.1128/MCB.26.8.3114-3123.2006. PMC 1446966. PMID 16581786.
• Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P (August 2006). "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)". Leukemia Research. 30 (8): 1037–42. doi:10.1016/j.leukres.2005.10.014. PMID 16303180.
• Lu Z, Kim KA, Suico MA, Shuto T, Li JD, Kai H (March 2004). "MEF up-regulates human beta-defensin 2 expression in epithelial cells". FEBS Letters. 561 (1–3): 117–21. Bibcode:2004FEBSL.561..117L. doi:10.1016/S0014-5793(04)00138-3. PMID 15013761. S2CID 86612269.
• Suico MA, Yoshida H, Seki Y, Uchikawa T, Lu Z, Shuto T, Matsuzaki K, Nakao M, Li JD, Kai H (April 2004). "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein". The Journal of Biological Chemistry. 279 (18): 19091–8. doi:10.1074/jbc.M312439200. PMID 14976184.
• Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P, Zhang DE, Libermann TA (May 2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". The Journal of Biological Chemistry. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.
• Hedvat CV, Yao J, Sokolic RA, Nimer SD (February 2004). "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells". The Journal of Biological Chemistry. 279 (8): 6395–400. doi:10.1074/jbc.M307524200. PMID 14625302.
• Suico MA, Koyanagi T, Ise S, Lu Z, Hisatsune A, Seki Y, Shuto T, Isohama Y, Miyata T, Kai H (August 2002). "Functional dissection of the ETS transcription factor MEF". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1577 (1): 113–20. doi:10.1016/s0167-4781(02)00370-6. PMID 12151102.
• Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (May 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
• Aryee DN, Petermann R, Kos K, Henn T, Haas OA, Kovar H (March 1998). "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1". Gene. 210 (1): 71–8. doi:10.1016/S0378-1119(98)00022-5. PMID 9524226.

External links

• ELF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)