Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[5][6][7]

EDF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEDF1, EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDsOMIM: 605107; MGI: 1891227; HomoloGene: 2809; GeneCards: EDF1; OMA:EDF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153200
NM_001281297
NM_001281298
NM_001281299
NM_003792

NM_021519

RefSeq (protein)

NP_001268226
NP_001268227
NP_001268228
NP_003783
NP_694880

NP_067494

Location (UCSC)Chr 9: 136.86 – 136.87 MbChr 2: 25.45 – 25.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[7]

Interactions

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EDF1 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107223Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015092Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. doi:10.1074/jbc.273.47.31119. PMID 9813014.
  6. ^ Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMC 11146030. PMID 15112053. S2CID 861006.
  7. ^ a b "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
  8. ^ a b c Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
  9. ^ Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
  10. ^ Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.

Further reading

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