EDEM1

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.

EDEM1
Identifiers
Aliases	EDEM1, EDEM, ER degradation enhancing alpha-mannosidase like protein 1
External IDs	OMIM: 607673 MGI: 2180139 HomoloGene: 33836 GeneCards: EDEM1
Gene location (Human) Chr. Chromosome 3 (human) Band 3p26.1 Start 5,187,646 bp End 5,219,958 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 E2 Start 108,805,602 bp End 108,836,317 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells thymus liver right lobe of liver lymph node appendix thymus stromal cell of endometrium monocyte trabecular bone Top expressed in lacrimal gland thymus parotid gland crypt of lieberkuhn of small intestine left lobe of liver submandibular gland islet of Langerhans seminal vesicula jejunum pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding misfolded protein binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity protein binding catalytic activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum endoplasmic reticulum quality control compartment Golgi membrane aggresome Biological process N-glycan processing positive regulation of retrograde protein transport, ER to cytosol trimming of terminal mannose on C branch IRE1-mediated unfolded protein response response to unfolded protein ubiquitin-dependent glycoprotein ERAD pathway mannose trimming involved in glycoprotein ERAD pathway ubiquitin-dependent ERAD pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9695 192193 Ensembl ENSG00000134109 ENSMUSG00000030104 UniProt Q92611 Q925U4 RefSeq (mRNA) NM_014674 NM_138677 RefSeq (protein) NP_055489 NP_619618 Location (UCSC) Chr 3: 5.19 – 5.22 Mb Chr 6: 108.81 – 108.84 Mb PubMed search
Wikidata
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Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Hosokawa N, Wada I, Hasegawa K, et al. (2001). "A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation". EMBO Rep. 2 (5): 415–22. doi:10.1093/embo-reports/kve084. PMC 1083879. PMID 11375934.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Oda Y, Hosokawa N, Wada I, Nagata K (2003). "EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin". Science. 299 (5611): 1394–7. doi:10.1126/science.1079181. PMID 12610305. S2CID 28716209.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olivari S, Galli C, Alanen H, et al. (2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J. Biol. Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
• Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
• Hosokawa N, Wada I, Natsuka Y, Nagata K (2006). "EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin". Genes Cells. 11 (5): 465–76. doi:10.1111/j.1365-2443.2006.00957.x. PMID 16629899. S2CID 19832510.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Zuber C, Cormier JH, Guhl B, et al. (2007). "EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4407–12. Bibcode:2007PNAS..104.4407Z. doi:10.1073/pnas.0700154104. PMC 1810509. PMID 17360537.