Protein ECT2 is a protein that in humans is encoded by the ECT2 gene.[4][5][6]

ECT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesECT2, ARHGEF31, epithelial cell transforming 2
External IDsOMIM: 600586; MGI: 95281; HomoloGene: 7298; GeneCards: ECT2; OMA:ECT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258315
NM_001258316
NM_018098

NM_001177625
NM_001177626
NM_007900

RefSeq (protein)

NP_001171096
NP_001171097
NP_031926

Location (UCSC)n/aChr 3: 27.15 – 27.21 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.[6]

Interactions

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ECT2 has been shown to interact with PARD6A.[7]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027699Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Miki T, Smith CL, Long JE, Eva A, Fleming TP (Apr 1993). "Oncogene ect2 is related to regulators of small GTP-binding proteins". Nature. 362 (6419): 462–5. Bibcode:1993Natur.362..462M. doi:10.1038/362462a0. PMID 8464478. S2CID 722736.
  5. ^ Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T (Dec 1999). "Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis". J. Cell Biol. 147 (5): 921–8. doi:10.1083/jcb.147.5.921. PMC 2169345. PMID 10579713.
  6. ^ a b "Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene".
  7. ^ Liu XF, Ishida H, Raziuddin R, Miki T (Aug 2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862. PMID 15254234.

Further reading

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