EAPP

E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene.

EAPP
Identifiers
Aliases	EAPP, BM036, C14orf11, E2F associated phosphoprotein
External IDs	OMIM: 609486; MGI: 1913516; HomoloGene: 10206; GeneCards: EAPP; OMA:EAPP - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q13.1 Start 34,515,938 bp End 34,539,704 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C1 Start 54,717,125 bp End 54,742,682 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon palpebral conjunctiva olfactory zone of nasal mucosa rectum mucosa of transverse colon skin of leg left ovary skin of abdomen white blood cell ganglionic eminence Top expressed in interventricular septum yolk sac medial ganglionic eminence morula seminiferous tubule otic placode epithelium of lens granulocyte neural tube otic vesicle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55837 66266 Ensembl ENSG00000129518 ENSMUSG00000054302 UniProt Q56P03 Q5BU09 RefSeq (mRNA) NM_018453 NM_001318916 NM_025456 NM_001331162 RefSeq (protein) NP_001305845 NP_060923 NP_001318091 NP_079732 Location (UCSC) Chr 14: 34.52 – 34.54 Mb Chr 12: 54.72 – 54.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kamnasaran D, Chen CP, Devriendt K, et al. (2005). "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes". Genomics. 85 (5): 608–21. doi:10.1016/j.ygeno.2005.01.010. PMID 15820313.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.