Wikipedia

E. Sally Ward

For the aristocrat, see Sallie Ward.

Elizabeth Sally Ward FRS is a British physician who is Director of Translational Immunology at the Centre for Cancer Immunology in the University of Southampton.[1][2] She was elected Fellow of the Royal Society in 2022.[3]

Sally Ward
FRS
Born
Elizabeth Sally Ward
Alma materUniversity of Cambridge
AwardsRoyal Society Wolfson Research Merit Award (2018)
Scientific career
FieldsImmunology
Cancer Biology
Antibody Engineering
Antibody Therapeutics[1]
InstitutionsTexas A&M University
University of Texas Southwestern Medical Center
University of Cambridge
University of Southampton
ThesisMolecular genetics of an insectidal delta-endotoxin from Bacillus thuringiensis var israelensis. (1985)
Doctoral advisorDavid J. Ellar
Websitewww.wardoberlab.com/lab-members/sally-ward/ Edit this at Wikidata

Early life and education edit

Ward was an undergraduate student at the University of Cambridge, where she studied the Natural Sciences Tripos with a focus on biochemistry. She remained at Cambridge for her doctoral research, working under the supervision of David J. Ellar at Gonville and Caius College, Cambridge.[4][5][6] Her PhD research investigated the genetics of delta endotoxin from Bacillus thuringiensis israelensis.[7]

Research and career edit

Ward remained at Cambridge as a junior research fellow, working in both Gonville and Caius College and Sidney Sussex College, Cambridge.[8]

In 1990, Ward moved to the United States. She joined the University of Texas Southwestern Medical Center, where she was a member of the founding team of the Centre for Immunology. She was awarded various named chairs in Texas, including the Paul and Betty Meek-FINA Professorship. In 1996, Ward identified the Fc receptor, a regulator of Immunoglobulin G levels.[9] She moved to the Texas A&M University Health Sciences University in 2014.[9] In 2018, Ward returned to the United Kingdom, joining the University of Southampton as Professor of Molecular Immunology and Director of Translational Immunology.[10][11]

Ward works on antibody and protein engineering to treat autoimmune disease.[12] She makes use of in vivo studies to design novel anti-body therapies for the treatment of cancer. Her early identification of the Fc receptor has resulted in the development of FcRn antagonist technologies.[13][14] Ward has licensed these Abdegs (antibodies that enhance IgG degradation) to the pharmaceutical industry, resulting in anti-body therapeutics.[9][14][15]

Ward has developed advanced microscopies and image analysis techniques. She has demonstrated single molecule spectroscopy is capable of imaging single protein molecules at exceptional resolution. She uses multi-colour imaging to interrogate the cell surfaces. Using these approaches, Ward visualised the biological pathways intracellular endoscopes to the plasma membrane (and vice versa).[12] She has also pioneered open access software packages for miroscopy analysis.[12]

Awards and honours edit

Selected publications edit

  • Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli[16]
  • Localization accuracy in single-molecule microscopy"[17]
  • Multiple roles for the major histocompatibility complex class I- related receptor FcRn[18]
  • Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies[19]

References edit

  1. ^ a b E. Sally Ward publications indexed by Google Scholar  
  2. ^ E. Sally Ward publications from Europe PubMed Central
  3. ^ a b Anon (2022). "Sally Ward FRS". royalsociety.org. London: Royal Society. Retrieved 2022-05-11.
  4. ^ Anon (2020). "Professor David Ellar (1939 - 2020)". cai.cam.ac.uk.
  5. ^ Susana Vilchez (3 December 2020). "A Tribute to a <i>Bacillus thuringiensis</i> Master: Professor David J. Ellar". Toxins. 12 (12). doi:10.3390/TOXINS12120764. ISSN 2072-6651. PMID 33287128. Wikidata Q104108938.
  6. ^ Anon (2018). "Cancer Institute Seminar Series - Prof Sally Ward". ucl.ac.uk. UCL Cancer Institute. Retrieved 2022-05-11.
  7. ^ Ward, Elizabeth Sally (1985). Molecular genetics of an insectidal delta-endotoxin from Bacillus thuringiensis var israelensis. cam.ac.uk (PhD thesis). University of Cambridge. OCLC 499855244. EThOS uk.bl.ethos.377842.
  8. ^ Anon. "Home". wardoberlab.com. WardOber Lab. Retrieved 2022-05-11.
  9. ^ a b c d "Sally Ward, Ph.D." antibodysociety.org. The Antibody Society. Retrieved 2022-05-11.
  10. ^ Anon (2019). "Lab Members". wardoberlab.com. WardOber Lab. Retrieved 2022-05-11.
  11. ^ "Interview with Sally Ward and Raimund Ober". southampton.ac.uk. Centre for Cancer Immunology. Retrieved 2022-05-11.
  12. ^ a b c Anon (2019). "Research Interests". wardoberlab.com. Retrieved 2022-05-11.
  13. ^ "SELECTBIO - High-Content and Phenotypic Screening Europe 2018 Speaker Biography". selectbiosciences.com. Retrieved 2022-05-11.
  14. ^ a b "More than two decades of UTSW research paves way for first-in-kind drug". utsouthwestern.edu. 3 January 2022. Retrieved 2022-05-11.
  15. ^ "Married scientists developing breakthrough cancer drugs urge people to Stand Up To Cancer". dailyecho.co.uk. Daily Echo. 14 October 2021. Retrieved 2022-05-11.
  16. ^ Ward ES; Güssow D; Griffiths AD; Jones PT; Winter G (1 October 1989). "Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli". Nature. 341 (6242): 544–546. doi:10.1038/341544A0. ISSN 1476-4687. PMID 2677748. Wikidata Q35896400.
  17. ^ Raimund J. Ober; Sripad Ram; E. Sally Ward (1 February 2004). "Localization accuracy in single-molecule microscopy". Biophysical Journal. 86 (2): 1185–1200. doi:10.1016/S0006-3495(04)74193-4. ISSN 0006-3495. PMC 1303911. PMID 14747353. Wikidata Q34184690.
  18. ^ Ghetie V; Ward ES (1 January 2000). "Multiple roles for the major histocompatibility complex class I- related receptor FcRn". Annual Review of Immunology. 18: 739–766. doi:10.1146/ANNUREV.IMMUNOL.18.1.739. ISSN 0732-0582. PMID 10837074. Wikidata Q33932754.
  19. ^ Ober RJ; Radu CG; Ghetie V; Ward ES (1 December 2001). "Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies". International Immunology. 13 (12): 1551–1559. doi:10.1093/INTIMM/13.12.1551. ISSN 0953-8178. PMID 11717196. Wikidata Q34102657.
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