Draft:Lixazinone

Lixazinone
INN: lixazinone
Clinical data
AHFS/Drugs.com	Monograph
Identifiers
	IUPAC name N-cyclohexyl-N-methyl-4-((1,2,3,5-tetrahydro-2-oxoimidazo(2,1-B)quinazolin07-yl)oxy)-butanamide;
CAS Number	94192-59-3 ;
PubChem CID	135434015;
UNII	0FK7P66P1X;
ChEMBL	ChEMBL69139 ;
Chemical and physical data
Formula	C21H28N4O3
Molar mass	384.480 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.33±0.1 g/cm3
Melting point	243 to 244 °C (469 to 471 °F)
	SMILES CN(C1CCCCC1)C(=O)CCCOC2=CC3=C(NC4=NC(=O)CN4C3)C=C2;
	InChI InChI=1S/C21H28N4O3/c1-24(16-6-3-2-4-7-16)20(27)8-5-11-28-17-9-10-18-15(12-17)13-25-14-19(26)23-21(25)22-18/h9-10,12,16H,2-8,11,13-14H2,1H3,(H,22,23,26; Key:WUECXCBONAGRSA-UHFFFAOYSA-N;

Lixazinone is an investigational drug.

Medical uses edit

Lixazinone is an inhibitor of cyclic adenosine monophosphate phosphodiesterase isoform 3^[1]

Lixazinone is achiral. It is available as a sulfate salt.

^ Cheng, Jingfei; Thompson, Michael A.; Walker, Henry J.; Gray, Catherine E.; Warner, Gina M.; Zhou, Wei; Grande, Joseph P. (March 2006). "Lixazinone Stimulates Mitogenesis of Madin-Darby Canine Kidney Cells". Experimental Biology and Medicine. 231 (3): 288–295. doi:10.1177/153537020623100308. PMID 16514175. S2CID 43318008.