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Facundo Damian Batista is a professor of biology at MIT, the chief editor of the EMBO Journal,. and an associate director, scientific director, and principal investigator at the Ragon Institute[1] of Mass General, MIT[2], and Harvard[3]. An expert in B cells[4] and antibodies, he studies their fundamental biology and their applications to immunology and vaccine development.
Raised in Argentina, Batista developed a passion for molecular biology at the University of Buenos Aires[5]. He earned his Master of Science degree in biology in 1993 and a Ph.D. in biology in 1995 from the International School of Advanced Studies[6] in Trieste.
From 1996 to 2002, Batista trained with Michael Neuberger[7] as an EMBO Postdoctoral Fellow at the MRC Laboratory of Molecular Biology[8] in Cambridge. There, Batista and Neuberger researched the relationship between B cell responses and antigen affinity, publishing their findings in Immunity[9] and Nature[10].
Joining the Ragon Institute in 2016, Batista established a research group that studies the mechanisms of B cell activation,which helps support vaccine development[11]. In 2017, Batista helped create a technique for developing human antibodies in the laboratory[12]. The method helps accelerate the process of developing therapeutic antibodies[13]. It also supports vaccine development, allowing researchers to test them in artificial immune systems[14] before clinical trials.
Batista’s work at the Ragon Institute developed technical innovations for the genetic engineering of mice[15] with humanized B cell receptors. The resulting animal models enable researchers to test vaccines.. The technique also led to a new HIV vaccine design strategy and could support the development of vaccines against the flu, dengue, malaria and hepatitis C.[16] Batista and the team published their findings from this line of research in The EMBO Journal[17] and Science[18].
References
edit- ^ "Ragon Institute", Wikipedia, 2024-05-15, retrieved 2024-08-01
- ^ "Massachusetts Institute of Technology", Wikipedia, 2024-07-31, retrieved 2024-08-01
- ^ "Harvard University", Wikipedia, 2024-07-29, retrieved 2024-08-01
- ^ "B cell", Wikipedia, 2024-07-13, retrieved 2024-08-01
- ^ "University of Buenos Aires", Wikipedia, 2024-06-28, retrieved 2024-08-01
- ^ "International School for Advanced Studies", Wikipedia, 2024-01-03, retrieved 2024-08-01
- ^ "Michael Neuberger", Wikipedia, 2024-04-06, retrieved 2024-08-01
- ^ "MRC Laboratory of Molecular Biology", Wikipedia, 2024-07-01, retrieved 2024-08-01
- ^ Batista, Facundo (June 1, 1998). "Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate". Immunity.
- ^ Batista, Facundo D.; Iber, Dagmar; Neuberger, Michael S. (May 2001). "B cells acquire antigen from target cells after synapse formation". Nature. 411 (6836): 489–494. doi:10.1038/35078099. ISSN 1476-4687. PMID 11373683.
- ^ "Germline-Targeting Approach Defined for HIV Vaccine". www.precisionvaccinations.com. Retrieved 2024-08-01.
- ^ "Technique Rapidly Generates Monoclonal Antibodies In Vitro". The Scientist Magazine®. Retrieved 2024-08-01.
- ^ "Technique Rapidly Generates Monoclonal Antibodies In Vitro". The Scientist Magazine®. Retrieved 2024-08-01.
- ^ "Test-tube Immune Systems Can Speed Vaccine Development". Voice of America. 2017-07-24. Retrieved 2024-08-01.
- ^ "One-step method developed to generate mice for vaccine research". Drug Target Review. Retrieved 2024-08-01.
- ^ "Germline-Targeting Approach Defined for HIV Vaccine". www.precisionvaccinations.com. Retrieved 2024-08-01.
- ^ Wang, Xuesong; Ray, Rashmi; Kratochvil, Sven; Melzi, Eleonora; Lin, Ying-Cing; Giguere, Sophie; Xu, Liling; Warner, John; Cheon, Diane; Liguori, Alessia; Groschel, Bettina; Phelps, Nicole; Adachi, Yumiko; Tingle, Ryan; Wu, Lin (2021-01-15). "Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors". The EMBO Journal. 40 (2). doi:10.15252/embj.2020105926. ISSN 0261-4189. PMC 7809789. PMID 33258500.
- ^ Giguère, Sophie; Wang, Xuesong; Huber, Sabrina; Xu, Liling; Warner, John; Weldon, Stephanie R.; Hu, Jennifer; Phan, Quynh Anh; Tumang, Katie; Prum, Thavaleak; Ma, Duanduan; Kirsch, Kathrin H.; Nair, Usha; Dedon, Peter; Batista, Facundo D. (2024-01-12). "Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand". Science. 383 (6679): 205–211. Bibcode:2024Sci...383..205G. doi:10.1126/science.adi1763. ISSN 0036-8075. PMC 10954030. PMID 38207021.