Wikipedia

Draft:Debprasad Dutta

Debprasad Dutta
Achieved Best Poster Award from Padma Shri Prof. B. N. Gangadhar, Honourable Director of NIMHANS at Symposium on “Yoga & Indian Psychology” in 2017 [Courtesy: NIMHANS Photography section]
NationalityIndian
CitizenshipIndia
Alma materBurdwan Raj College (B.Sc.)

The University of Burdwan (M.Sc.)

National Institute of Mental Health and Neuro Sciences (NIMHANS) (P.hD.)

University of Liverpool (Postgraduate Visiting Scholar)
Known forImmuno-susceptibility of Guillain Barre syndrome
AwardsDeveloping Country Award from the American Society of Human Genetics (ASHG) AWSAR Award from DST-India
Scientific career
FieldsTranslational Neuroscience
InstitutionsResearch Scientist at Mazumdar Shaw Medical Foundation (MSMF), Narayana Health City, Bommasandra Industrial Area, Bangalore
Thesis Guillain Barre Syndrome: Comprehensive Profiling of Infectious Triggers, Genetic Predisposition, Ganglioside & Ganglioside Complex Autoantibodies  (2022)
Doctoral advisorProf. Monojit Debnath, Prof. Vasanthapuram Ravi, Prof. Madhu Nagappa
Other academic advisorsProf. Tom Solomon Prof. Arun B. Taly
Felicitated by Hon'ble Minister of Health & Family Welfare and Medical Education of Karnataka, Dr. K Sudhakar in the gracious presence of Dr. Mansukh Mandaviya (MOHFW, GOI) and Shri T C Gehlot, Governor of Karnataka, Debprasad Dutta received a Degree of Philosophy in Human Genetics. [ Courtesy: NIMHANS Photography section]
Felicitated by Hon'ble Minister of Health & Family Welfare and Medical Education of Karnataka, Dr. K Sudhakar in the gracious presence of Dr. Mansukh Mandaviya (MOHFW, GOI) and Shri T C Gehlot, Governor of Karnataka, Debprasad Dutta received Doctor of Philosophy completion certificate in Human Genetics.[1] [ Courtesy: NIMHANS Photography section

Debprasad Dutta MSc, MRSB, Ph.D. is an Indian-born scientist specialized in translational neuroscience. He is popularly known as Dr. Deb.[2] He currently works as the Research Scientist at Mazumdar Shaw Medical Foundation (MSMF), Narayana Health (NH) City, Bommasandra Industrial Area, Bangalore.[3] He has been granted Commonwealth Split-site Scholarship from Department for International Development (DFID), the Government of the United Kingdom (UK) scholarships.[4] His name has been enlisted in the Interactive Database of Life Science Researchers in India curated by IndiaBioscience.[5]

Education edit

He graduated from Burdwan Raj College (2010-2013) and received his Master's from The University of Burdwan in 2015.[6][7] Dutta earned PhD in Human Genetics from the renowned National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore in 2022.[8][9] He was a postgraduate researcher at the Institute of Infection, Veterinary, Ecology Sciences (IVES), University of Liverpool, England under supervision of Prof. Tom Solomon, Director of The Pandemic Institute, Liverpool.[4][10]

Career edit

Debprasad Dutta has been working as Research Scientist at Mazumdar Shaw Center for Translational Research (MSCTR), MSMF since 2022.[3] He has published several original research articles, review articles and book chapters in reputed scholarly journals, books and conference proceedings.[11][12][13] He was invited as Peer-Reviewer by BMC Neurology, [14] Scientific Reports[15] and Insider Imprint, the internal life science journal of the University of Liverpool, UK.[16][17]

Research edit

Dutta's research is on translational neuroscience, especially neuroimmunology.[4] He is an expert of Guillain Barre Syndrome (GBS),[18][19] a rare neurological disorder in which human immune system mistakenly attacks part of the peripheral nervous system typically causing symmetric paralysis. His Ph.D. thesis-work titled “Guillain Barre Syndrome: Comprehensive Profiling of Infectious Triggers, Genetic Predisposition, Ganglioside & Ganglioside Complex Autoantibodies”, was the first and largest comprehensive investigation on GBS conducted from India.[20] His research was funded by CDC, DST-SERB and ICMR with the guidance of Dr. Monojit Debnath, Dr. Vasanthapuram Ravi, Dr. Madhu Nagappa.[21] GBS prevails in most of his publications.[22] In a large case-control study, he showed diverse antecedent infections in GBS patients from South India,[23] and lack of evidence of prior Zika virus infection in GBS.[24] Moreover, his research reported that Chikungunya was the commonest antecedent infection in the Indian cohort of GBS followed by C. jejuni.[23] Alongside he demonstrated that antecedent infections can modulate the response on the autoantibodies against gangliosides and ganglioside complexes in GBS.[25][26]

Dr. Deb further looked into the association of genetic risk factors especially polymorphisms in Toll Like Receptor (TLR) genes on GBS. He discovered, Del/Del genotype rs111200466 and CT genotype of rs3804099 of TLR-2 gene were significantly associated with the risk of GBS.[27] He has also contributed in deciphering the role of cytokines in the progression and recovery of GBS and the importance of the Th17 pathway in GBS[28] and proposed therapeutic potential of Th17 pathway signatures in GBS.[29][30] In another study, the same research group reported elevated levels of cytokines of the Th17 pathway in the cerebrospinal fluid (CSF) samples from patients with GBS substantiating the implication of CSF analysis in establishing the diagnosis of GBS.[31] He has written an popular science article titled "Why Can’t I feel My Feet?: Antibodies Playing on the Nerve Floor"[20] which was shortlisted for Augmenting Writing Skills for Articulating Research (AWSAR) award from the Department of Science and Technology (DST), Government of India.[32] In addition, Dr. Deb reviewed mechanistic and evolutionary changes of antibiotic resistance among bacteria extensively.[33] He authored a book chapter about neurological impact of COVID-19.[34] He has also made an article entry in the Scholarly Community Encyclopedia titled "Antibiotics and Their Impact on Bacterial Cellular Perturbation".[35]

His most recent research work focused on stem cell-based stroke management with adjunct hyperbaric oxygen therapy.[3] At Mazumdar Shaw Center for Translational Research (MSCTR), he and his colleagues initiated Integrated Research on Neuroscience (IRoN) initiative in collaboration with Narayana Institute of Neuroscience (NIN), NH funded by SKAN Research Trust..[36]

Awards and achievements edit

Debprasad Dutta has achieved numerous awards and distictions. Dutta received Commonwealth Split-site PhD Scholarship', from DFID, Government of UK in 2019.[4] He achieved Developing Country Award from the American Society of Human Genetics (ASHG) in recognition of the best-selected abstracts on PhD research work at the ASHG annual meeting in San Diego, USA in 2020.[8][37][38]

He was honored by AWSAR award for ‘Best PhD Stories’ by National Council of Science and Technology Communication (NCSTC), Department of Science & Technology, Government of India on National Science Day in 2020.[20][39]

Science communication and public engagement edit

Dutta has membership of learned societies such as VALIDATE Network (Oxford University) and American Society for Peripheral Nerve (ASPN).[2]

He is known to engage in cross-disciplinary activities. His Breaking News article titled “Molecular mimicry: perfect match propels pathologies” published in Immunopaedia newsletter of International Union of Immunological Societies (IUIS), October 2020.[40] He contributed a policy recommendation article titled “Commonwaste of Commonwealth: Healthcare Waste as by-Product of Response against COVID-19” in Association of Commonwealth Scholars and Fellows (ACSF-India) Bulletin on August 15, 2022.[41]

References edit

  1. ^ 'M➜D' Transversion: From Mr. to Dr. Debprasad Dutta with Health Minister #shorts, retrieved 2023-02-23
  2. ^ a b "ASPN - Synapse". peripheralnerve.org. Retrieved 2023-02-23.
  3. ^ a b c K, Kanagaraj (2022-10-11). "Debprasad Dutta". MSCTR | Cancer Research |Translational Research. Retrieved 2023-02-22.
  4. ^ a b c d K, Kanagaraj (2022-10-11). "Debprasad Dutta". MSCTR | Cancer Research |Translational Research. Retrieved 2023-07-27.
  5. ^ "This interactive #mapviz serves to locate, connect and help foster collaborations and cross-disciplinary interactions within the community of #lifescientists in #India". Tableau Software. Retrieved 2023-02-23.
  6. ^ "debprasad dutta education - Google Search". www.google.com. Retrieved 2023-07-27.
  7. ^ "www.asianbiographies.com". www.asianbiographies.in. Retrieved 2023-07-27.
  8. ^ a b "nimhans.ac.in/wp-content/uploads/2022/09/NIMHANS_AR_2020-21_English.pdf" (PDF).
  9. ^ "Badge Evidence". badges.wes.org. Retrieved 2023-07-27.
  10. ^ Frost, Nicola (2022-05-25). "Professor Tom Solomon appointed Director of The Pandemic Institute - University of Liverpool News". News. Retrieved 2023-02-22.
  11. ^ "DEBPRASAD DUTTA". scholar.google.co.in. Retrieved 2023-02-21.
  12. ^ "Scopus preview - Dutta, Debprasad - Author details - Scopus". www.scopus.com. Retrieved 2023-02-23.
  13. ^ "Web of Science". www.webofscience.com. Retrieved 2023-02-23.
  14. ^ Ma, Linzhuo; Liu, Shuping; Xiao, Zheman; Guan, Jingxia; Liu, Yin; Yao, Jiajia; Lu, Zuneng (December 2022). "bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02567-8/peer-review". BMC Neurology. 22 (1): 46. doi:10.1186/s12883-022-02567-8. PMC 8817496. PMID 35123436.
  15. ^ "reviewer-feedback.nature.com/archive/2022/12".
  16. ^ "Insider Imprint The life sciences journal for undergraduate and masters students at the University of Liverpool". Spring (4): 2. 2021. ISSN 2516-256X.
  17. ^ "Insider Imprint, the Health & Life Sciences Journal for Undergraduate and Master Students at the University of Liverpool". Spring (5): 2. 2022. ISSN 2516-256X.
  18. ^ "Debprasad Dutta | Academic Influence". academicinfluence.com. Retrieved 2023-03-06.
  19. ^ "Guillain-Barre Syndrome: Dutta, Debprasad - Expertscape.com". expertscape.com. Retrieved 2023-03-06.
  20. ^ a b c "Why Can't I feel My Feet?: Antibodies Playing on the Nerve Floor". scholar.google.com. Retrieved 2023-02-21.
  21. ^ "nimhans.ac.in/wp-content/uploads/2019/10/NIMHANS-Annual-Report-2017-18.pdf" (PDF).
  22. ^ "Dutta D - Search Results - PubMed". PubMed. Retrieved 2023-03-06.
  23. ^ a b "Antecedent infections in Guillain‐Barré syndrome patients from south India". scholar.google.com. Retrieved 2023-02-21.
  24. ^ "LACK OF EVIDENCE OF ANTECEDENT ZIKA VIRUS INFECTION IN GUILLAIN-BARRE SYNDROME PATIENTS HOSPITALIZED IN A REFERRAL HOSPITAL IN SOUTH INDIA, 2014-2016". scholar.google.com. Retrieved 2023-02-21.
  25. ^ Dutta, Debprasad; Debnath, Monojit; Seshagiri, DoniparthiV; Sreekumaran Nair, BinuV; Das, SumitK; Wahatule, Rahul; Sinha, Sanjib; Ravi, Vasanthapuram; Taly, ArunB; Nagappa, Madhu (2022). "Impact of antecedent infections on the antibodies against gangliosides and ganglioside complexes in Guillain-Barré syndrome: A correlative study". Annals of Indian Academy of Neurology. 25 (3): 401–406. doi:10.4103/aian.aian_121_22. ISSN 0972-2327. PMC 9350806. PMID 35936588.
  26. ^ "Ganglioside complex antibodies in an Indian cohort of Guillain‐Barré syndrome". scholar.google.com. Retrieved 2023-02-21.
  27. ^ "Mediators of toll-like receptor (TLR) pathway as genetic determinants of Guillain Barre syndrome". scholar.google.com. Retrieved 2023-02-21.
  28. ^ Debnath, Monojit; Nagappa, Madhu; Dutta, Debprasad; Talukdar, Pinku Mani; Subbanna, Manjula; Shivakumar, Venkataram; Wahatule, Rahul; Sinha, Sanjib; Bindu, Parayil Sankaran; Periyavan, Sundar; Umamaheswara Rao, G. S.; Kumar, Malathi Anil; Taly, Arun B. (2020-05-01). "Evidence of altered Th17 pathway signatures in the cerebrospinal fluid of patients with Guillain Barré Syndrome". Journal of Clinical Neuroscience. 75: 176–180. doi:10.1016/j.jocn.2020.03.010. ISSN 0967-5868. PMID 32217048. S2CID 214609472.
  29. ^ Debnath, Monojit; Nagappa, Madhu; Subbanna, Manjula; Sundaravadivel, Pandarisamy; Talukdar, Pinku Mani; Shivakumar, Venkataram; Wahatule, Rahul; Dutta, Debprasad; Binukumar, B.; Sinha, Sanjib; Bindu, Parayil Sankaran; Periyavan, Sundar; Umamaheswara Rao, G. S.; Taly, Arun B. (2018-10-15). "Th17 pathway signatures in a large Indian cohort of Guillain Barré syndrome". Journal of Neuroimmunology. 323: 125–130. doi:10.1016/j.jneuroim.2018.08.001. ISSN 0165-5728. PMID 30196825. S2CID 52177041.
  30. ^ Debnath, Monojit; Nagappa, Madhu; Talukdar, Pinku Mani; Subbanna, Manjula; Sundaravadivel, P.; Shivakumar, Venkataram; Dutta, Debprasad; Wahatule, Rahul; Sinha, Sanjib; Bindu, Parayil Sankaran; Periyavan, Sundar; Umamaheswara Rao, G. S.; Taly, Arun B. (2018-10-01). "Comprehensive cytokine profiling provides evidence for a multi-lineage Th responses in Guillain Barré Syndrome". Cytokine. 110: 58–62. doi:10.1016/j.cyto.2018.04.026. ISSN 1043-4666. PMID 29704819. S2CID 13683279.
  31. ^ Debnath, Monojit; Nagappa, Madhu; Dutta, Debprasad; Wahatule, Rahul; Taly, Arun B. (2021-08-01). "P-PN035. TH17 pathway-related cytokine abnormalities in the plasma and cerebrospinal fluid in Guillain Barré Syndrome (GBS): A correlation analysis". Clinical Neurophysiology. 132 (8): e116. doi:10.1016/j.clinph.2021.02.283. ISSN 1388-2457. S2CID 235816503.
  32. ^ Dutta, Debprasad (2020), Sharma, R.; Tyagi, B. K.; Bhushan, K. B.; Jain, G. (eds.), "Why Can't I Feel My Feet? : Antibodies Playing on the Nerve Floor", AWSAR Awarded Popular Science Stories: by Scientists for the People, New Delhi, Delhi, India: Vigyan Prasar, pp. 335–338, retrieved 2023-02-22
  33. ^ Hasan, Chowdhury M.; Dutta, Debprasad; Nguyen, An N. T. (2021-12-30). "Revisiting Antibiotic Resistance: Mechanistic Foundations to Evolutionary Outlook". Antibiotics. 11 (1): 40. doi:10.3390/antibiotics11010040. ISSN 2079-6382. PMC 8773413. PMID 35052917.
  34. ^ "Neurological impact of COVID-19 pandemic: Lessons & cautions". scholar.google.com. Retrieved 2023-02-21.
  35. ^ "Antibiotics and Their Impact on Bacterial Cellular Perturbation". encyclopedia.pub. Retrieved 2023-02-23.
  36. ^ "Integrated Research on Neuroscience". MSCTR | Cancer Research |Translational Research. Retrieved 2023-02-22.
  37. ^ Md 20852. "Past Award Recipients". ASHG. Retrieved 2023-02-23.{{cite web}}: CS1 maint: numeric names: authors list (link)
  38. ^ "Developing Coutntry Award 2020 from the American Society of Human Genetics".
  39. ^ "AWSAR Award 2020 For Science Communication from the Government of India".
  40. ^ "Molecular mimicry: perfect match propels pathologies | Immunopaedia". Immunopaedia | Advancing global immunology education. 2020-10-09. Retrieved 2023-03-06.
  41. ^ "ACSF_Newsletter" (PDF).
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