Draft:Carmantadine

Carmantadine
Clinical data
Other names	SCH-15427; NSC-172618
Identifiers
	IUPAC name 1-(1-adamantyl)azetidine-2-carboxylic acid;
CAS Number	38081-67-3;
PubChem CID	37906;
ChemSpider	34751;
UNII	6EK3N87MMH;
KEGG	D03407;
ChEMBL	ChEMBL2106463;
Chemical and physical data
Formula	C14H21NO2
Molar mass	235.327 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(C1C(=O)O)C23CC4CC(C2)CC(C4)C3;
	InChI InChI=1S/C14H21NO2/c16-13(17)12-1-2-15(12)14-6-9-3-10(7-14)5-11(4-9)8-14/h9-12H,1-8H2,(H,16,17); Key:VPBLOJFGPORKQA-UHFFFAOYSA-N;

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Instructions · What links here · Carmantadine (talk: + · bio) · (log) · Copyvios report · reFill · Citation Bot · (Search: Google, Bing, Wikipedia) · Submitted 97 minutes ago by 76.174.0.57 (talk: D · +) · Last edited 2 minutes ago by Boghog

Carmantadine (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code name SCH-15427) is an antiparkinsonian agent of the adamantane group that was never marketed.^[1]^[2]^[3]^[4] It is structurally related to amantadine and shares some of its pharmacological actions.^[2] Another related drug is dopamantine.^[2]^[3]^[4] Carmantadine was first described by 1972 and is said to have reached early clinical trials.^[1]^[2]^[3]^[4]

References

^ ^a ^b Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 13. ISBN 978-1-4757-2085-3. Retrieved 13 September 2024.
^ ^a ^b ^c ^d Vernier VG, du Pont E (1974). "Chapter 3. Antiparkinsonism Drugs". In Heinzelman RV (ed.). Annual Reports in Medicinal Chemistry. Vol. 9. Elsevier. pp. 19–26. doi:10.1016/s0065-7743(08)61424-4. ISBN 978-0-12-040509-1. Carmantadine (VII, Sch 151427) is structurally related to amantadine33. It shares some of its pharmacological actions, was effective in a head—turning test34 and is in early clinical trials.
^ ^a ^b ^c Barnett A, Goldstein J, Taber R, Fiedler E (January 1974). "Pharmacology of Dopamantine and Carmantadine, 2 Potential Antiparkinson Agents". Pharmacologist. 16 (2): 205–.
^ ^a ^b ^c Goldstein J, Barnett A (January 1974). "Antagonism of electrically-induced heart-turning (HT) following intracaudate administration of dopamine (DA), amantadine (AM), apomorphine (APO), dopamantine and carmantadine". Pharmacologist. 16 (2): 206.

[Elks2014-1] Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 13. ISBN 978-1-4757-2085-3. Retrieved 13 September 2024.

[VernierduPont1974-2] Vernier VG, du Pont E (1974). "Chapter 3. Antiparkinsonism Drugs". In Heinzelman RV (ed.). Annual Reports in Medicinal Chemistry. Vol. 9. Elsevier. pp. 19–26. doi:10.1016/s0065-7743(08)61424-4. ISBN 978-0-12-040509-1. Carmantadine (VII, Sch 151427) is structurally related to amantadine33. It shares some of its pharmacological actions, was effective in a head—turning test34 and is in early clinical trials.

[BarnettGoldsteinTaber1974-3] Barnett A, Goldstein J, Taber R, Fiedler E (January 1974). "Pharmacology of Dopamantine and Carmantadine, 2 Potential Antiparkinson Agents". Pharmacologist. 16 (2): 205–.

[GoldsteinBarnett1974-4] Goldstein J, Barnett A (January 1974). "Antagonism of electrically-induced heart-turning (HT) following intracaudate administration of dopamine (DA), amantadine (AM), apomorphine (APO), dopamantine and carmantadine". Pharmacologist. 16 (2): 206.

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