Draft:Aminitrozole

Aminitrozole
INN: aminitrozole
Clinical data
Trade names	Nithiamide, Tritheon, Nitazole
Other names	acinitrazole
Identifiers
	IUPAC name N-(5-nitro-1,3-thiazol-2-yl)acetamide;
CAS Number	140-40-9;
PubChem CID	8798;
ChemSpider	8468;
UNII	9CBM60191Z;
KEGG	D05176;
ChEBI	CHEBI:134832;
ChEMBL	ChEMBL1872946;
Chemical and physical data
Formula	C5H5N3O3S
Molar mass	187.17 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.598 ± 0.06 g/cm3
Melting point	267 to 270 °C (513 to 518 °F)
	SMILES O=C(NC1=NC=C(S1)N(=O)=O)C;
	InChI InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9); Key:UJRRDDHEMZLWFI-UHFFFAOYSA-N;

Aminitrozole was a drug used for the treatment of enterohepatitis in poultry, and was additionally investigated for the treatment of vaginal trichomoniasis.^[1]

Medical uses edit

Vetrinary edit

Aminitrozole introduction of it into poultry feed was observed to suppress both histomoniasis and coccidiosis in poultry.^[2]

Vaginal trichomoniasis edit

Aminitrozole was first used in 1956 as an oral medication for vaginal trichomoniasis, a sexually transmitted disease caused by the protozoan T. vaginalis. At the time, it was found to eliminate the presence of parasites in 35% of patients treated.^[3] However, a follow-up study in 1957 found no change in parasite levels following oral administration in a group of 35 patients.^[1]

Aminitrozole has shown in vitro growth reduction of T. vaginalis, and may be an alternative treatment in highly resistant trichomoniasis infections.^[4]

References edit

^ ^a ^b Willcox, R. R. (1 June 1957). "Treatment of Vaginal Trichomoniasis with 2-Acetylamino-5-Nitrothiazole (Aminitrozole) given Orally". Sexually Transmitted Infections. 33 (2): 115–117. doi:10.1136/sti.33.2.115.
^ GRUMBLES, LC; BONEY WA, Jr; TURK, RD (July 1952). "Chemotherapy of enterohepatitis of turkeys. I. The value of 2-amino-5-nitrothiazole in prevention and treatment". American journal of veterinary research. 13 (48): 383–5. PMID 12976638.
^ Plentl, Albert A.; Gray, Mary Jane; Neslen, Earl D.; Dalali, Salim J. (January 1956). "The clinical evaluation of 2-acetylamino-5-nitro-thiazole, an orally effective trichomonacide". American Journal of Obstetrics and Gynecology. 71 (1): 116–120. doi:10.1016/0002-9378(56)90686-X.
^ Goodhew, E Brook; Secor, W Evan (September 2013). "Drug library screening against metronidazole-sensitive and metronidazole-resistant Trichomonas vaginalis isolates". Sexually Transmitted Infections. 89 (6): 479–484. doi:10.1136/sextrans-2013-051032.

External links edit

[Willcox_1957-1] Willcox, R. R. (1 June 1957). "Treatment of Vaginal Trichomoniasis with 2-Acetylamino-5-Nitrothiazole (Aminitrozole) given Orally". Sexually Transmitted Infections. 33 (2): 115–117. doi:10.1136/sti.33.2.115.

[Grumbles_1952-2] GRUMBLES, LC; BONEY WA, Jr; TURK, RD (July 1952). "Chemotherapy of enterohepatitis of turkeys. I. The value of 2-amino-5-nitrothiazole in prevention and treatment". American journal of veterinary research. 13 (48): 383–5. PMID 12976638.

[Plentl_1956-3] Plentl, Albert A.; Gray, Mary Jane; Neslen, Earl D.; Dalali, Salim J. (January 1956). "The clinical evaluation of 2-acetylamino-5-nitro-thiazole, an orally effective trichomonacide". American Journal of Obstetrics and Gynecology. 71 (1): 116–120. doi:10.1016/0002-9378(56)90686-X.

[Goodhew_2013-4] Goodhew, E Brook; Secor, W Evan (September 2013). "Drug library screening against metronidazole-sensitive and metronidazole-resistant Trichomonas vaginalis isolates". Sexually Transmitted Infections. 89 (6): 479–484. doi:10.1136/sextrans-2013-051032.

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