 | Draft article not currently submitted for review.
This is a draft Articles for creation (AfC) submission. It is not currently pending review. While there are no deadlines, abandoned drafts may be deleted after six months. To edit the draft click on the "Edit" tab at the top of the window. To be accepted, a draft should:
It is strongly discouraged to write about yourself, your business or employer. If you do so, you must declare it. Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
Last edited by Citation bot (talk | contribs) 2 days ago. (Update) |
An acceptor splice region or acceptor splice site, also known as 3' splice site, is the downstream part of an intron, found at its 3' end.[1][2] The spliced site usually conserves the consensus dinucleotide AG.[2] This region, along with the donor site (5' end of the intron)[3] and branch site (near the 3' end of the intron), is essential for the accurate RNA splicing, to allow accurate removal of its corresponding intron from the RNA transcript. An acceptor splice region spans, on average, 28 bases.[3][1]
Mechanism of action
editTypes
editThere are several types of acceptor splice regions, classified by their nucleotide sequence and other factors.
Canonical acceptor splice sites
editThis type of site is the most common, being present in
Mutations
editReferences
edit- ^ a b "RNA Splicing | Learn Science at Scitable". www.nature.com. Retrieved 2024-09-11.
- ^ a b Baten, AKMA; Chang, BCH; Halgamuge, SK; Li, Jason (2006-12-18). "Splice site identification using probabilistic parameters and SVM classification". BMC Bioinformatics. 7 (5): S15. doi:10.1186/1471-2105-7-S5-S15. ISSN 1471-2105. PMC 1764471. PMID 17254299.
- ^ a b Caminsky, Natasha; Mucaki, Eliseos J.; Rogan, Peter K. (2014-11-18). "Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis". F1000Research. 3: 282. doi:10.12688/f1000research.5654.1. ISSN 2046-1402. PMC 4329672. PMID 25717368.