dnaS or dut is a gene involved in DNA replication in Escherichia coli. It encodes dUTP nucleotidohydrolase, an enzyme responsible for catalyzing the conversion of dUTP to dUMP, thereby ensuring that the organism's DNA contains the nucleobase thymine instead of uracil.[1]
| Deoxyuridine 5'-triphosphate nucleotidohydrolase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | dut | ||||||
| Alt. symbols | dnaS; ECK3630; JW3615; sof | ||||||
| NCBI gene | 948607 | ||||||
| UniProt | P06968 | ||||||
| Other data | |||||||
| EC number | 3.6.1.23 | ||||||
| |||||||
See also
editReferences
edit- ^ el-Hajj HH, Zhang H, Weiss B (March 1988). "Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli". Journal of Bacteriology. 170 (3): 1069–75. doi:10.1128/jb.170.3.1069-1075.1988. PMC 210875. PMID 2830228.
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