Diacylglycerol O-acyltransferase 2

Diacylglycerol O-acyltransferase 2 (DGAT2) is a protein that in humans is encoded by the DGAT2 gene. [5]

DGAT2
Identifiers
AliasesDGAT2, ARAT, GS1999FULL, HMFN1045, diacylglycerol O-acyltransferase 2
External IDsOMIM: 606983; MGI: 1915050; HomoloGene: 23580; GeneCards: DGAT2; OMA:DGAT2 - orthologs
EC number2.3.1.76
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253891
NM_032564

NM_026384

RefSeq (protein)

NP_001240820
NP_115953

NP_080660

Location (UCSC)Chr 11: 75.76 – 75.8 MbChr 7: 98.8 – 98.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs.

The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000062282Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030747Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Diacylglycerol O-acyltransferase 2". Retrieved 2017-07-18.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.