Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during parturition.[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.[2]

Denaverine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • Gr 1 (Germany)
Routes of
administration
intramuscular injection, suppositories
ATCvet code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability8% (suppositories),
37% (oral solution)
Metabolismmainly hepatic, at least 11 metabolites
Elimination half-life34 hours
Identifiers
  • 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H33NO3
Molar mass383.532 g·mol−1
3D model (JSmol)
  • CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
  • InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3 ☒N
  • Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Mechanism of action

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Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.[3]

References

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  1. ^ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
  2. ^ Dootz H, Kuhlmann A, Hoffmann K, eds. (2005). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
  3. ^ Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.