Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.[3][4][5]

TNFRSF10D
Identifiers
AliasesTNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10d, TNF receptor superfamily member 10d
External IDsOMIM: 603614; HomoloGene: 136778; GeneCards: TNFRSF10D; OMA:TNFRSF10D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003840

n/a

RefSeq (protein)

NP_003831

n/a

Location (UCSC)Chr 8: 23.14 – 23.16 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

edit

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain.

This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.[5]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173530Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol. 7 (12): 1003–6. Bibcode:1997CBio....7.1003M. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840. S2CID 21645158.
  4. ^ Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling" (PDF). FEBS Lett. 424 (1–2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512. S2CID 2964615.
  5. ^ a b "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

Further reading

edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.