Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily.[3][4][5]

TNFRSF10C
Identifiers
AliasesTNFRSF10C, CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID, tumor necrosis factor receptor superfamily member 10c, TNF receptor superfamily member 10c
External IDsOMIM: 603613; HomoloGene: 48244; GeneCards: TNFRSF10C; OMA:TNFRSF10C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003841

n/a

RefSeq (protein)

NP_003832

n/a

Location (UCSC)Chr 8: 23.1 – 23.12 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173535Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA (Nov 1997). "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family". J Exp Med. 186 (7): 1165–70. doi:10.1084/jem.186.7.1165. PMC 2199077. PMID 9314565.
  4. ^ MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES (Nov 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J Biol Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.
  5. ^ a b "Entrez Gene: TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.