Daz interacting zinc finger protein 3

E3 ubiquitin-protein ligase DZIP3 is a protein that in humans is encoded by the DZIP3 gene.

DZIP3
Identifiers
Aliases	DZIP3, PPP1R66, UURF2, hRUL138, DAZ interacting zinc finger protein 3
External IDs	OMIM: 608672 MGI: 1917433 HomoloGene: 8771 GeneCards: DZIP3
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B5 Start 48,744,595 bp End 48,814,528 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell Brodmann area 23 sperm Achilles tendon middle temporal gyrus right uterine tube superior frontal gyrus postcentral gyrus entorhinal cortex tibia Top expressed in superior cervical ganglion hand ventromedial nucleus arcuate nucleus mammillary body paraventricular nucleus of hypothalamus lateral hypothalamus dorsomedial hypothalamic nucleus median eminence supraoptic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase binding polyubiquitin modification-dependent protein binding protein binding metal ion binding RNA binding ubiquitin-protein transferase activity transferase activity unfolded protein binding ubiquitin protein ligase activity ubiquitin-specific protease binding Cellular component cytoplasm Hrd1p ubiquitin ligase complex Derlin-1 retrotranslocation complex endoplasmic reticulum quality control compartment Biological process protein polyubiquitination protein ubiquitination ubiquitin-dependent ERAD pathway endoplasmic reticulum unfolded protein response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9666 224170 Ensembl n/a ENSMUSG00000064061 UniProt Q86Y13 Q7TPV2 RefSeq (mRNA) NM_014648 NM_001110017 NM_027341 NM_001356425 RefSeq (protein) NP_055463 NP_001103487 NP_081617 NP_001343354 Location (UCSC) n/a Chr 16: 48.74 – 48.81 Mb PubMed search
Wikidata
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Further reading

• Zhou W, Zhu P, Wang J, Pascual G, Ohgi KA, Lozach J, Glass CK, Rosenfeld MG (2008). "Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation". Mol. Cell. 29 (1): 69–80. doi:10.1016/j.molcel.2007.11.002. PMC 2327256. PMID 18206970.