DYNC1LI1

Cytoplasmic dynein 1 light intermediate chain 1 is a protein that in humans is encoded by the DYNC1LI1 gene.

DYNC1LI1
Identifiers
Aliases	DYNC1LI1, DNCLI1, LIC1, dynein cytoplasmic 1 light intermediate chain 1, DLC-A
External IDs	OMIM: 615890; MGI: 2135610; HomoloGene: 9403; GeneCards: DYNC1LI1; OMA:DYNC1LI1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p22.3 Start 32,525,974 bp End 32,570,858 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F3 Start 114,517,858 bp End 114,553,370 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right ventricle ganglionic eminence gonad lateral nuclear group of thalamus pons testicle gastrocnemius muscle ventricular zone biceps brachii Top expressed in neural layer of retina granulocyte interventricular septum gastrula primary visual cortex right kidney muscle of thigh superior frontal gyrus ankle decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity nucleotide binding GDP binding dynein heavy chain binding GTP binding protein binding cytoskeletal motor activity ATP binding RNA binding Cellular component centrosome spindle pole membrane chromosome cytoplasmic dynein complex dynein complex microtubule chromosome, centromeric region cytoskeleton kinetochore cytoplasm cytosol plasma membrane secretory granule membrane ficolin-1-rich granule membrane Biological process positive regulation of mitotic cell cycle spindle assembly checkpoint cell division cell cycle viral process microtubule cytoskeleton organization endoplasmic reticulum to Golgi vesicle-mediated transport microtubule-based movement antigen processing and presentation of exogenous peptide antigen via MHC class II neutrophil degranulation sister chromatid cohesion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51143 235661 Ensembl ENSG00000144635 ENSMUSG00000032435 UniProt Q9Y6G9 Q8R1Q8 RefSeq (mRNA) NM_016141 NM_001329135 NM_146229 RefSeq (protein) NP_001316064 NP_057225 NP_666341 Location (UCSC) Chr 3: 32.53 – 32.57 Mb Chr 9: 114.52 – 114.55 Mb PubMed search
Wikidata
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Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Tynan SH, Purohit A, Doxsey SJ, Vallee RB (2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin". J. Biol. Chem. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222.
• Bielli A, Thörnqvist PO, Hendrick AG, et al. (2001). "The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1". Biochem. Biophys. Res. Commun. 281 (5): 1141–53. doi:10.1006/bbrc.2001.4468. PMID 11243854.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.