Protein delta homolog 1, delta like non-canonical Notch ligand 1, fetal antigen 1[5] or preadipocyte factor 1[6] is a protein that in humans is encoded by the DLK1 gene.[7][8][9]

DLK1
Identifiers
AliasesDLK1, DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2, AW742678, DlkI, Ly107, Peg9, SCP1, delta like non-canonical Notch ligand 1
External IDsOMIM: 176290; MGI: 94900; HomoloGene: 2846; GeneCards: DLK1; OMA:DLK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032997
NM_003836
NM_001317172

NM_001190703
NM_001190704
NM_001190705
NM_010052

RefSeq (protein)

NP_001304101
NP_003827
NP_003827.3

NP_001177632
NP_001177633
NP_001177634
NP_034182

Location (UCSC)Chr 14: 100.73 – 100.74 MbChr 12: 109.42 – 109.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis,[10] the differentiation of pre-adipocytes into adipocytes.[11]

It is a member of the EGF-like family of homeotic proteins.[12]

Part of the Dlk1-DIO3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin.[13]

Such imprinted genes are required for the formation of the placenta as well as the development of cellular lineages such as those derived from the mesoderm and ectoderm.[14]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185559Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040856Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jensen C, Teisner B, Højrup P, Rasmussen H, Madsen O, Nielsen B, Skjødt K (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2". Human Reproduction. 8 (4): 635–641. doi:10.1093/oxfordjournals.humrep.a138110. PMID 8501199.
  6. ^ Smas CM, Sul HS (1993). "Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation". Cell. 73 (4): 725–734. doi:10.1016/0092-8674(93)90252-L. PMID 8500166. S2CID 23634189.
  7. ^ Laborda J, Sausville EA, Hoffman T, Notario V (1993). "dlk, a Putative Mammalian Homeotic Gene Differentially Expressed in Small Cell Lung Carcinoma and Neuroendocrine Tumor Cell Line". The Journal of Biological Chemistry. 268 (6): 3817–20. doi:10.1016/S0021-9258(18)53544-4. PMID 8095043.
  8. ^ Jensen CH, Krogh TN, Højrup P, Clausen PP, Skjødt K, Larsson LI, Enghild JJ, Teisner B (1994). "Protein Structure of Fetal Antigen 1 (FA1). A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene Products of Dlk and pG2". European Journal of Biochemistry. 225 (1): 83–92. doi:10.1111/j.1432-1033.1994.00083.x. PMID 7925474.
  9. ^ EntrezGene 8788
  10. ^ Wang Y, Sul HS (2009). "Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9". Cell Metabolism. 9 (3): 287–302. doi:10.1016/j.cmet.2009.01.013. PMC 2673480. PMID 19254573.
  11. ^ Adipogenesis at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  12. ^ Laborda J (2000). "The role of the epidermal growth factor-like protein dlk in cell differentiation". Histology and Histopathology. 15 (1): 119–29. PMID 10668203.
  13. ^ Lin SP, Coan P, da Rocha ST, Seitz H, Cavaille J, Teng PW, Takada S, Ferguson-Smith AC (Jan 2007). "Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region". Development. 134 (2): 417–426. doi:10.1242/dev.02726. PMID 17166925.
  14. ^ Hernandez A, Fiering S, Martinez E, Galton VA, St Germain D (Nov 2002). "The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts". Endocrinology. 143 (11): 4483–4486. doi:10.1210/en.2002-220800. PMID 12399446.

Further reading

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