ATP-dependent RNA helicase DDX50 is an enzyme that in humans is encoded by the DDX50 gene.[5][6]

DDX50
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDDX50, GU2, GUB, RH-II/GuB, mcdrh, DEAD-box helicase 50, DExD-box helicase 50
External IDsOMIM: 610373; MGI: 2182303; HomoloGene: 56986; GeneCards: DDX50; OMA:DDX50 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024045

NM_053183
NM_001358819
NM_001358820

RefSeq (protein)

NP_076950

NP_444413
NP_001345748
NP_001345749

Location (UCSC)Chr 10: 68.9 – 68.95 MbChr 10: 62.45 – 62.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107625Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020076Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Valdez BC, Yang H, Hong E, Sequitin AM (Mar 2002). "Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs". Gene. 284 (1–2): 53–61. doi:10.1016/S0378-1119(01)00888-5. PMID 11891046.
  6. ^ a b "Entrez Gene: DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50".

Further reading

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