DDR1

For the type of computer memory, see DDR SDRAM.

Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.

DDR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZOS, 4AG4, 4BKJ, 4CKR, 5BVK, 5BVN, 5BVO, 5BVW, 5FDP
Identifiers
Aliases	DDR1, CAK, CD167, DDR, EHGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, discoidin domain receptor tyrosine kinase 1
External IDs	OMIM: 600408; MGI: 99216; HomoloGene: 68212; GeneCards: DDR1; OMA:DDR1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 30,876,421 bp End 30,900,156 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.7 cM Start 35,992,459 bp End 36,015,513 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone right uterine tube ganglionic eminence olfactory zone of nasal mucosa C1 segment minor salivary glands islet of Langerhans skin of abdomen mucosa of esophagus substantia nigra Top expressed in ciliary body iris Epithelium of choroid plexus retinal pigment epithelium conjunctival fornix Rostral migratory stream medial ganglionic eminence epithelium of stomach motor neuron parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity collagen binding metal ion binding kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase collagen receptor activity protein tyrosine kinase activity ATP binding receptor tyrosine kinase Cellular component integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane extracellular region extracellular exosome extracellular space Biological process collagen-activated tyrosine kinase receptor signaling pathway branching involved in mammary gland duct morphogenesis phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway female pregnancy extracellular matrix organization ear development mammary gland alveolus development regulation of extracellular matrix disassembly smooth muscle cell migration smooth muscle cell-matrix adhesion regulation of cell-matrix adhesion protein phosphorylation cell adhesion regulation of cell growth peptidyl-tyrosine phosphorylation lactation wound healing, spreading of cells embryo implantation negative regulation of cell population proliferation peptidyl-tyrosine autophosphorylation protein autophosphorylation axon development neuron projection extension cell-matrix adhesion positive regulation of cell population proliferation cell differentiation regulation of extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 780 12305 Ensembl ENSG00000215522 ENSG00000137332 ENSG00000229767 ENSG00000230456 ENSG00000234078 ENSG00000204580 ENSG00000223680 ENSMUSG00000003534 UniProt Q08345 Q03146 RefSeq (mRNA) NM_001202521 NM_001202522 NM_001202523 NM_001297652 NM_001297653 NM_001297654 NM_001954 NM_013993 NM_013994 NM_001198831 NM_001198833 NM_007584 NM_172962 RefSeq (protein) NP_001189450 NP_001189451 NP_001189452 NP_001284581 NP_001284582 NP_001284583 NP_001945 NP_054699 NP_054700 NP_001284583.1 NP_054699.2 NP_001185760 NP_001185762 NP_031610 NP_766550 Location (UCSC) Chr 6: 30.88 – 30.9 Mb Chr 17: 35.99 – 36.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the DDR2 protein. In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Further reading

• Edelhoff S, Sweetser DA, Disteche CM (Jan 1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C". Genomics. 25 (1): 309–11. doi:10.1016/0888-7543(95)80144-B. PMID 7774938.
• Shelling AN, Butler R, Jones T, Laval S, Boyle JM, Ganesan TS (Jan 1995). "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16". Genomics. 25 (2): 584–7. doi:10.1016/0888-7543(95)80065-T. PMID 7789998.
• Weiner TM, Liu ET, Craven RJ, Cance WG (Jan 1994). "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors". Annals of Surgical Oncology. 1 (1): 18–27. doi:10.1007/BF02303537. PMID 7834423. S2CID 2737602.
• Laval S, Butler R, Shelling AN, Hanby AM, Poulsom R, Ganesan TS (Nov 1994). "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line". Cell Growth & Differentiation. 5 (11): 1173–83. PMID 7848919.
• Kato JY, Matsuoka M, Strom DK, Sherr CJ (Apr 1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". Molecular and Cellular Biology. 14 (4): 2713–21. doi:10.1128/MCB.14.4.2713. PMC 358637. PMID 8139570.
• Di Marco E, Cutuli N, Guerra L, Cancedda R, De Luca M (Nov 1993). "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues". The Journal of Biological Chemistry. 268 (32): 24290–5. doi:10.1016/S0021-9258(20)80524-9. hdl:11380/607761. PMID 8226977.
• Perez JL, Shen X, Finkernagel S, Sciorra L, Jenkins NA, Gilbert DJ, Copeland NG, Wong TW (Jan 1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene. 9 (1): 211–9. PMID 8302582.
• Johnson JD, Edman JC, Rutter WJ (Jun 1993). "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain". Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5677–81. Bibcode:1993PNAS...90.5677J. doi:10.1073/pnas.90.12.5677. PMC 46784. PMID 8390675.
• Perez JL, Jing SQ, Wong TW (Apr 1996). "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines". Oncogene. 12 (7): 1469–77. PMID 8622863.
• Valent A, Meddeb M, Danglot G, Duverger A, Nguyen VC, Bernheim A (Jul 1996). "Assignment of the NTRK4 (trkE) gene to chromosome 6p21". Human Genetics. 98 (1): 12–5. doi:10.1007/s004390050152. PMID 8682498. S2CID 9450185.
• Playford MP, Butler RJ, Wang XC, Katso RM, Cooke IE, Ganesan TS (Jul 1996). "The genomic structure of discoidin receptor tyrosine kinase". Genome Research. 6 (7): 620–7. doi:10.1101/gr.6.7.620. PMID 8796349.
• Sakuma S, Saya H, Tada M, Nakao M, Fujiwara T, Roth JA, Sawamura Y, Shinohe Y, Abe H (Dec 1996). "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein". FEBS Letters. 398 (2–3): 165–9. doi:10.1016/S0014-5793(96)01234-3. PMID 8977099. S2CID 7573214.
• Nemoto T, Ohashi K, Akashi T, Johnson JD, Hirokawa K (1998). "Overexpression of protein tyrosine kinases in human esophageal cancer". Pathobiology. 65 (4): 195–203. doi:10.1159/000164123. PMID 9396043.
• Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, Kuma K, Yamashita S, Niwa M (Mar 1998). "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid". Endocrinology. 139 (3): 852–8. doi:10.1210/endo.139.3.5791. PMID 9492013.
• Vogel W, Gish GD, Alves F, Pawson T (Dec 1997). "The discoidin domain receptor tyrosine kinases are activated by collagen". Molecular Cell. 1 (1): 13–23. doi:10.1016/S1097-2765(00)80003-9. PMID 9659899.
• Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD (Dec 1997). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular Cell. 1 (1): 25–34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900.
• Vogel W, Brakebusch C, Fässler R, Alves F, Ruggiero F, Pawson T (Feb 2000). "Discoidin domain receptor 1 is activated independently of beta(1) integrin". The Journal of Biological Chemistry. 275 (8): 5779–84. doi:10.1074/jbc.275.8.5779. PMID 10681566.
• Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA (May 2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB Journal. 14 (7): 973–81. doi:10.1096/fasebj.14.7.973. PMID 10783152. S2CID 43317719.
• Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB (Dec 2000). "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors". Neurosurgery. 47 (6): 1400–9. doi:10.1097/00006123-200012000-00028. PMID 11126911. S2CID 2299503.
• Mohan RR, Mohan RR, Wilson SE (Jan 2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea". Experimental Eye Research. 72 (1): 87–92. doi:10.1006/exer.2000.0932. PMID 11133186.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.