D-value may refer to:
- D-value (microbiology) - the decimal reduction time, the time required at a certain temperature to kill 90% of the organisms being studied
- D-value (meteorology) in meteorology refers to the deviation of actual altitude along a constant pressure surface from the standard atmosphere altitude of that surface.
- D-value (transport) - a rating in kN that is typically attributed to mechanical couplings
- Cohen's d in statistics - The expected difference between the means between an experimental group and a control group, divided by the expected standard deviation. It is used in estimations of necessary sample sizes of experiments.
- d', a sensitivity index.
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