Cytokine dependent hematopoietic cell linker

Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene. [5]

CLNK
Identifiers
AliasesCLNK, MIST, cytokine dependent hematopoietic cell linker
External IDsOMIM: 611434; MGI: 1351468; HomoloGene: 8450; GeneCards: CLNK; OMA:CLNK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052964

NM_013748

RefSeq (protein)

NP_443196

NP_038776

Location (UCSC)Chr 4: 10.49 – 10.68 MbChr 5: 38.86 – 39.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109684Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039315Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Cytokine dependent hematopoietic cell linker". Retrieved 2017-09-06.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.