Complement receptor of the immunoglobulin family

Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cells.[1] It is a critical receptor for the phagocytosis of opsonised particles in the blood. It recognizes iC3b (inactivated C3b) deposited on microbial surfaces.

V-set and immunoglobulin domain containing 4
Identifiers
SymbolVSIG4
NCBI gene11326
HGNC17032
OMIM300353
RefSeqNM_007268
UniProtQ9Y279
Other data
LocusChr. X q12-q13.3
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StructuresSwiss-model
DomainsInterPro

See also

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References

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  1. ^ Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, Scales S, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.