Coiled-Coil Domain Containing Protein – 25

The Coiled-Coil Domain Containing Protein – 25 (CCDC25) is a human protein whose function is not presently understood.

CCDC25
Identifiers
Aliases	CCDC25, Coiled-Coil Domain Containing Protein – 25, coiled-coil domain containing 25
External IDs	MGI: 1914429 HomoloGene: 6645 GeneCards: CCDC25
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.1 Start 27,733,316 bp End 27,772,653 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D1 Start 66,074,751 bp End 66,104,056 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon duodenum jejunal mucosa sural nerve corpus epididymis islet of Langerhans rectum left adrenal gland Top expressed in jejunum liver quadriceps femoris muscle lens ileum duodenum bone marrow colon placenta pancreas More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 55246 67179 Ensembl ENSG00000147419 ENSMUSG00000022035 UniProt Q86WR0 Q78PG9 RefSeq (mRNA) NM_001304529 NM_001304530 NM_001304532 NM_018246 NM_145944 RefSeq (protein) NP_001291458 NP_001291459 NP_001291461 NP_060716 NP_666056 Location (UCSC) Chr 8: 27.73 – 27.77 Mb Chr 14: 66.07 – 66.1 Mb PubMed search
Wikidata
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Gene

The gene encoding the CCDC25 protein is located at 8p21.1, on the short arm of human chromosome 8, and is transcribed into an mRNA product approximately 3,583 nucleotides in length.

Protein

General

The protein is highly conserved among mammals as well as eukaryotes as diverse as Arabidopsis thaliana. CCDC25 is made up of a single polypeptide chain 208 amino acids in length and is expressed at a high level, nearly 4.2 times that of a normal human protein. Its expression is nearly ubiquitous in human tissues with little indication that its expression level changes drastically in diseased tissues. Despite currently lacking a well understood function, CCDC25 is predicted to localize to the nucleus and was shown by a microarray experiment to be upregulated in Metaphase II oocytes.

Interactions

CCDC25 was shown by a yeast-two-hybrid assay to interact with Smad2, a latent transcription factor that is part of the TGF-β signaling pathway. The protein is a predicted substrate of Casein Kinase 1, Casein Kinase 2, cGMP-dependent protein kinase, and the Insulin Receptor; all of which have well defined roles in cell signaling.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.