Chromosome 19 open reading frame 33

Chromosome 19 open reading frame 33 is a protein that in humans is encoded by the C19orf33 gene.[5]

C19orf33
Identifiers
AliasesC19orf33, H2RSP, IMUP, IMUP-1, IMUP-2, chromosome 19 open reading frame 33
External IDsMGI: 1919525; HomoloGene: 137645; GeneCards: C19orf33; OMA:C19orf33 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033520
NM_022125
NM_001317801

NM_028179

RefSeq (protein)

NP_001304730
NP_277055

NP_082455

Location (UCSC)Chr 19: 38.3 – 38.31 MbChr 7: 28.95 – 28.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167644Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030587Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Chromosome 19 open reading frame 33". Retrieved 2018-10-23.

Further reading

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  • Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M (October 2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochem. Biophys. Res. Commun. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055.
  • Kim JK, An HJ, Kim NK, Ahn JY, Kim KS, Kang YJ, Ko JJ, Oh D, Lee C, Kim SJ, Cha KY (2003). "IMUP-1 and IMUP-2 genes are up-regulated in human ovarian epithelial tumors". Anticancer Res. 23 (6C): 4709–13. PMID 14981917.
  • Naganuma S, Itoh H, Uchiyama S, Nagaike K, Tanaka H, Akiyama Y, Chijiiwa K, Kataoka H (March 2006). "Nuclear translocation of H2RSP is impaired in regenerating intestinal epithelial cells of murine colitis model". Virchows Arch. 448 (3): 354–60. doi:10.1007/s00428-005-0064-6. PMID 16189703. S2CID 1817907.
  • Betsunoh H, Mukai S, Akiyama Y, Fukushima T, Minamiguchi N, Hasui Y, Osada Y, Kataoka H (April 2007). "Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma". Cancer Sci. 98 (4): 491–8. doi:10.1111/j.1349-7006.2007.00412.x. PMC 11160002. PMID 17309599. S2CID 26220332.
  • Kim SJ, An HJ, Kim HJ, Jungs HM, Lee S, Ko JJ, Kim IH, Sakuragi N, Kim JK (2008). "Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean and Japanese populations". Anticancer Res. 28 (2A): 865–71. PMID 18507030.
  • Jeon SY, Lee HJ, Park JM, Jung HM, Yoo JK, Lee HJ, Lee JS, Cha DH, Kim JK, Kim GJ (May 2010). "Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia". J. Cell. Biochem. 110 (2): 522–30. doi:10.1002/jcb.22568. PMID 20432246. S2CID 42000298.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.