Chondroitin ABC lyase (EC 4.2.2.20 EC 4.2.2.21 , chondroitinase , chondroitin ABC eliminase , chondroitinase ABC ) is an enzyme with systematic name chondroitin ABC lyase .[1] [2] catalyses the following chemical reaction
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate.
Following a spinal cord injury , this enzyme can be used to erode scar tissue that can interfere with regeneration.[3]
References
edit
^ Yamagata T, Saito H, Habuchi O, Suzuki S (April 1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases" . The Journal of Biological Chemistry . 243 (7): 1523–35. doi :10.1016/S0021-9258(18)93574-X PMID 5647268 . ^ Saito H, Yamagata T, Suzuki S (April 1968). "Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates" . The Journal of Biological Chemistry . 243 (7): 1536–42. doi :10.1016/S0021-9258(18)93575-1 PMID 4231029 . ^ Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ (April 2014). "Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury" . The Journal of Neuroscience . 34 (14): 4822–36. doi :10.1523/JNEUROSCI.4369-13.2014 . PMC 3972714 PMID 24695702 .
External links
edit
