Charles Egerton may refer to:
- Charles Egerton (Indian Army officer) (1848–1921), senior British army officer
- Charles Egerton (MP for Ripon), 17th-century English politician
- Charles Egerton (MP for Brackley) (1645–1717)
- Charles Egerton (MP for Wycombe) (1694–1725), MP for Wycombe
- Charles Chandler Egerton (1798–1885), English surgeon
- Charles Egerton (racehorse trainer), in 2009 Grand National