Centrin-3 is a protein that in humans is encoded by the CETN3 gene.[4][5] It belongs to the centrin family of proteins.

CETN3
Identifiers
AliasesCETN3, CDC31, CEN3, centrin 3
External IDsOMIM: 602907; MGI: 1097706; HomoloGene: 74521; GeneCards: CETN3; OMA:CETN3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004365
NM_001297765
NM_001297768

NM_007684

RefSeq (protein)

NP_001284694
NP_001284697
NP_004356

NP_031710

Location (UCSC)Chr 5: 90.39 – 90.41 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153140Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Middendorp S, Paoletti A, Schiebel E, Bornens M (Sep 1997). "Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene". Proc Natl Acad Sci U S A. 94 (17): 9141–6. Bibcode:1997PNAS...94.9141M. doi:10.1073/pnas.94.17.9141. PMC 23077. PMID 9256449.
  5. ^ a b "Entrez Gene: CETN3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast)".
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Further reading

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