Centrin-2 is a protein that in humans is encoded by the CETN2 gene.[5][6][7] It belongs to the centrin family of proteins.

CETN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCETN2, CALT, CEN2, centrin 2
External IDsOMIM: 300006; MGI: 1347085; HomoloGene: 55798; GeneCards: CETN2; OMA:CETN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004344

NM_019405

RefSeq (protein)

NP_004335

NP_062278

Location (UCSC)Chr X: 152.83 – 152.83 MbChr X: 71.96 – 71.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrin-2 belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that centrin-2 plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.[7]

Interactions

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CETN2 has been shown to interact with XPC[8] and SFI1.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147400Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031347Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tanaka T, Okui K, Nakamura Y (May 1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization". Genomics. 24 (3): 609–10. PMID 7713520.
  6. ^ Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions". Mamm Genome. 6 (11): 802–4. doi:10.1007/BF00539008. PMID 8597638. S2CID 19420279.
  7. ^ a b "Entrez Gene: CETN2 centrin, EF-hand protein, 2".
  8. ^ Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. 276 (22). United States: 18665–72. doi:10.1074/jbc.M100855200. ISSN 0021-9258. PMID 11279143.
  9. ^ Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex". Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500.
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Further reading

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