Wikipedia

Carl-Philipp Heisenberg

Carl-Philipp Heisenberg (born 1968) is a German developmental biologist specializing in embryology, cell biology, and biophysics. He is the grandson of the physicist Werner Heisenberg and nephew of biologist Martin Heisenberg. He was born in Munich, Germany.

After graduating in Biology in Munich in 1992, he carried out his PhD work with Christiane Nüsslein-Volhard in Tübingen in 1997.[1] After a postdoc with Stephen Wilson at University College London,[2] he started his research group in 2001 at the Max Planck Institute for Cell Biology and Genetics in Dresden as an Emmy Noether junior professor.[3] Since 2010, he is a professor at the Institute of Science and Technology Austria.[4]

Heisenberg was elected member of the German National Academy of Sciences Leopoldina in 2015[5] and of the European Molecular Biology Organisation in 2016.[6] In 2019, he received the Carus medal from the Leopoldina.[7]

Heisenberg's research focuses on characterising the molecular, cellular and physical regulation of embryonic development.[4] Using mostly zebrafish as a model organism, his group has identified how cytoskeletal and adhesive elements control the physical properties of tissues during gastrulation.[8][9][10][11][12][13][14][15]

References edit

  1. ^ Heisenberg, C.P.; Brand, M.; Jiang, Y.J.; Warga, R.M.; Beuchle, D.; van Eeden, F.J.; Furutani-Seiki, M.; Granato, M.; Haffter, P.; Hammerschmidt, M.; Kane, D.A.; Kelsh, R.N.; Mullins, M.C.; Odenthal, J.; Nusslein-Volhard, C. (1 December 1996). "Genes involved in forebrain development in the zebrafish, Danio rerio". Development. 123 (1): 191–203. doi:10.1242/dev.123.1.191. PMID 9007240.
  2. ^ Heisenberg, Carl-Philipp; Tada, Masazumi; Rauch, Gerd-Jörg; Saúde, Leonor; Concha, Miguel L.; Geisler, Robert; Stemple, Derek L.; Smith, James C.; Wilson, Stephen W. (May 2000). "Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation". Nature. 405 (6782): 76–81. Bibcode:2000Natur.405...76H. doi:10.1038/35011068. PMID 10811221. S2CID 4397286.
  3. ^ "MPI-CBG: Alumni". www.mpi-cbg.de.
  4. ^ a b "Heisenberg Group".
  5. ^ "Mitglieder". Nationale Akademie der Wissenschaften Leopoldina.
  6. ^ "Find people in the EMBO Communities". people.embo.org.
  7. ^ "Carus Medal awarded to IST Austria professor Carl-Philipp Heisenberg".
  8. ^ Krieg, M.; Arboleda-Estudillo, Y.; Puech, P.-H.; Käfer, J.; Graner, F.; Müller, D. J.; Heisenberg, C.-P. (April 2008). "Tensile forces govern germ-layer organization in zebrafish". Nature Cell Biology. 10 (4): 429–436. doi:10.1038/ncb1705. PMID 18364700. S2CID 22340931.
  9. ^ Maitre, J.-L.; Berthoumieux, H.; Krens, S. F. G.; Salbreux, G.; Julicher, F.; Paluch, E.; Heisenberg, C.-P. (12 October 2012). "Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells". Science. 338 (6104): 253–256. Bibcode:2012Sci...338..253M. doi:10.1126/science.1225399. PMID 22923438. S2CID 7330288.
  10. ^ Behrndt, M.; Salbreux, G.; Campinho, P.; Hauschild, R.; Oswald, F.; Roensch, J.; Grill, S. W.; Heisenberg, C.-P. (12 October 2012). "Forces Driving Epithelial Spreading in Zebrafish Gastrulation". Science. 338 (6104): 257–260. Bibcode:2012Sci...338..257B. doi:10.1126/science.1224143. PMID 23066079. S2CID 34962468.
  11. ^ Ruprecht, Verena; Wieser, Stefan; Callan-Jones, Andrew; Smutny, Michael; Morita, Hitoshi; Sako, Keisuke; Barone, Vanessa; Ritsch-Marte, Monika; Sixt, Michael; Voituriez, Raphaël; Heisenberg, Carl-Philipp (February 2015). "Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility". Cell. 160 (4): 673–685. doi:10.1016/j.cell.2015.01.008. PMC 4328143. PMID 25679761.
  12. ^ Schwayer, Cornelia; Shamipour, Shayan; Pranjic-Ferscha, Kornelija; Schauer, Alexandra; Balda, Maria; Tada, Masazumi; Matter, Karl; Heisenberg, Carl-Philipp (October 2019). "Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow" (PDF). Cell. 179 (4): 937–952.e18. doi:10.1016/j.cell.2019.10.006. PMID 31675500. S2CID 204972165.
  13. ^ Petridou, Nicoletta I.; Corominas-Murtra, Bernat; Heisenberg, Carl-Philipp; Hannezo, Edouard (April 2021). "Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions". Cell. 184 (7): 1914–1928.e19. doi:10.1016/j.cell.2021.02.017. PMC 8055543. PMID 33730596.
  14. ^ Shamipour, Shayan; Kardos, Roland; Xue, Shi-Lei; Hof, Björn; Hannezo, Edouard; Heisenberg, Carl-Philipp (May 2019). "Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes". Cell. 177 (6): 1463–1479.e18. doi:10.1016/j.cell.2019.04.030. PMID 31080065.
  15. ^ Xia, Peng; Gütl, Daniel; Zheden, Vanessa; Heisenberg, Carl-Philipp (March 2019). "Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity". Cell. 176 (6): 1379–1392.e14. doi:10.1016/j.cell.2019.01.019. PMID 30773315.

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