Carboxynorspermidine synthase (EC 1.5.1.43, carboxynorspermidine dehydrogenase, carboxyspermidine dehydrogenase, CASDH, CANSDH) is an enzyme with systematic name carboxynorspermidine:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reactions
| Carboxynorspermidine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.1.43 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (1) carboxynorspermidine + H2O + NADP+ L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
- (2) carboxyspermidine + H2O + NADP+ L-aspartate 4-semialdehyde + putrescine + NADPH + H+
The reaction takes place in the opposite direction.
References edit
- ^ Nakao H, Shinoda S, Yamamoto S (July 1991). "Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus". Journal of General Microbiology. 137 (7): 1737–42. doi:10.1099/00221287-137-7-1737. PMID 1955861.
- ^ Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ (April 2009). "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae". The Journal of Biological Chemistry. 284 (15): 9899–907. doi:10.1074/jbc.M900110200. PMC 2665113. PMID 19196710.
- ^ Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ (December 2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota". The Journal of Biological Chemistry. 286 (50): 43301–12. doi:10.1074/jbc.M111.307835. PMC 3234850. PMID 22025614.
External links edit
- Carboxynorspermidine+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
