CYP2W1

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.

CYP2W1
Identifiers
Aliases	CYP2W1, cytochrome P450 family 2 subfamily W member 1
External IDs	OMIM: 615967 MGI: 3616076 HomoloGene: 69239 GeneCards: CYP2W1
Gene location (Human) Chr. Chromosome 7 (human) Band 7p22.3 Start 983,181 bp End 989,640 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 139,338,372 bp End 139,342,788 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava skin of abdomen internal globus pallidus sural nerve trabecular bone amniotic fluid pancreatic ductal cell duodenum body of tongue nipple Top expressed in lip zone of skin esophagus ileum colon stomach jejunum limb duodenum neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding oxidoreductase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding monooxygenase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Cellular component cell surface plasma membrane endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum membrane cytoplasm intracellular membrane-bounded organelle Biological process xenobiotic metabolic process epoxygenase P450 pathway organic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54905 545817 Ensembl ENSG00000073067 ENSMUSG00000029541 UniProt Q8TAV3 E9Q816 RefSeq (mRNA) NM_017781 NM_001160265 RefSeq (protein) NP_060251 NP_001153737 Location (UCSC) Chr 7: 0.98 – 0.99 Mb Chr 5: 139.34 – 139.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

External links

• Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294. S2CID 5123383.
• Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
• Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
• Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.