The Cyp11b3 is a rat gene encoding a CYP450 enzyme, which is mainly expressed in neonatal rat adrenals, and also expressed in a small amount in other organs of adult rats, this enzyme mainly catalyzing 11-Deoxycorticosterone (DOC) to 18-Hydroxy-11-deoxycorticosterone (18-OH-DOC).[1] Cyp11b3 gene is also located at Chromosome 7q34, next to rat CYP11B1 and CYP11B2.
| cytochrome P450, family 11, subfamily b, polypeptide 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | CYP11B3 | ||||||
| Entrez | 353498 | ||||||
| HomoloGene | 106948 | ||||||
| RefSeq (mRNA) | NM_181824.1 | ||||||
| RefSeq (Prot) | NP_861545.1 | ||||||
| UniProt | P30100 | ||||||
| Other data | |||||||
| EC number | 1.14.15.4 | ||||||
| Chromosome | 7: 116.16 - 116.26 Mb | ||||||
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References
edit- ^ Zhou MY, Gomez-Sanchez EP, Foecking MF, Gomez-Sanchez CE (October 1995). "Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC". Molecular and Cellular Endocrinology. 114 (1–2): 137–45. doi:10.1016/0303-7207(95)03653-o. PMID 8674838. S2CID 53252461.