CRHBP

Corticotropin-releasing factor-binding protein is a protein that in humans is encoded by the CRHBP gene. It belongs to corticotropin-releasing hormone binding protein family.

CRHBP
Identifiers
Aliases	CRHBP, CRF-BP, CRFBP, corticotropin releasing hormone binding protein
External IDs	OMIM: 122559; MGI: 88497; HomoloGene: 1418; GeneCards: CRHBP; OMA:CRHBP - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.3 Start 76,953,045 bp End 76,981,158 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D1|13 49.5 cM Start 95,567,879 bp End 95,581,432 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad spleen liver right lobe of liver prefrontal cortex testicle left adrenal cortex right adrenal cortex human kidney hypothalamus Top expressed in vestibular membrane of cochlear duct ciliary body iris lens lumbar subsegment of spinal cord hippocampus proper Region I of hippocampus proper visual cortex vestibular sensory epithelium amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function corticotropin-releasing hormone binding protein binding peptide binding Cellular component Golgi apparatus secretory granule endoplasmic reticulum perikaryon axon terminus dense core granule dendrite varicosity secondary lysosome multivesicular body microtubule extracellular region extracellular space intracellular anatomical structure nucleus Biological process negative regulation of corticotropin secretion female pregnancy cellular response to tumor necrosis factor regulation of corticotropin secretion cellular response to estrogen stimulus hormone-mediated signaling pathway behavioral response to ethanol learning or memory regulated exocytosis inflammatory response signal transduction cellular response to potassium ion cellular response to cocaine negative regulation of corticotropin-releasing hormone receptor activity synaptic transmission, dopaminergic maternal aggressive behavior hormone metabolic process cellular response to calcium ion cellular response to cAMP cellular response to estradiol stimulus cellular response to gonadotropin-releasing hormone regulation of NMDA receptor activity regulation of cellular response to stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1393 12919 Ensembl ENSG00000145708 ENSMUSG00000021680 UniProt P24387 Q60571 RefSeq (mRNA) NM_001882 NM_198408 RefSeq (protein) NP_001873 NP_940800 Location (UCSC) Chr 5: 76.95 – 76.98 Mb Chr 13: 95.57 – 95.58 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.

External links

• Human CRHBP genome location and CRHBP gene details page in the UCSC Genome Browser.

Further reading

• Behan DP, De Souza EB, Lowry PJ, et al. (1996). "Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides". Frontiers in Neuroendocrinology. 16 (4): 362–82. doi:10.1006/frne.1995.1013. PMID 8557170. S2CID 1704154.
• Westphal NJ, Seasholtz AF (2006). "CRH-BP: the regulation and function of a phylogenetically conserved binding protein". Front. Biosci. 11: 1878–91. doi:10.2741/1931. PMID 16368564.
• Potter E, Behan DP, Fischer WH, et al. (1991). "Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins". Nature. 349 (6308): 423–6. Bibcode:1991Natur.349..423P. doi:10.1038/349423a0. PMID 1846945. S2CID 4271589.
• Behan DP, Linton EA, Lowry PJ (1989). "Isolation of the human plasma corticotrophin-releasing factor-binding protein". J. Endocrinol. 122 (1): 23–31. doi:10.1677/joe.0.1220023. PMID 2549150.
• Behan DP, Heinrichs SC, Troncoso JC, et al. (1995). "Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease". Nature. 378 (6554): 284–7. Bibcode:1995Natur.378..284B. doi:10.1038/378284a0. PMID 7477348. S2CID 4305815.
• Vamvakopoulos NC, Sioutopoulou TO, Durkin SA, et al. (1995). "Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3)". Genomics. 25 (1): 325–7. doi:10.1016/0888-7543(95)80151-B. PMID 7774945.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Fischer WH, Behan DP, Park M, et al. (1994). "Assignment of disulfide bonds in corticotropin-releasing factor-binding protein". J. Biol. Chem. 269 (6): 4313–6. doi:10.1016/S0021-9258(17)41780-7. PMID 8307998.
• Donaldson CJ, Sutton SW, Perrin MH, et al. (1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5): 2167–70. doi:10.1210/endo.137.5.8612563. PMID 8612563.
• Asakura H, Zwain IH, Yen SS (1997). "Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary". J. Clin. Endocrinol. Metab. 82 (8): 2720–5. doi:10.1210/jcem.82.8.4119. PMID 9253360.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wetzka B, Sehringer B, Schäfer WR, et al. (2004). "Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term". Exp. Clin. Endocrinol. Diabetes. 111 (3): 154–61. doi:10.1055/s-2003-39778. PMID 12784189.
• Claes S, Villafuerte S, Forsgren T, et al. (2003). "The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden". Biol. Psychiatry. 54 (9): 867–72. doi:10.1016/S0006-3223(03)00425-6. PMID 14573312. S2CID 21112652.
• Sehringer B, Zahradnik HP, Simon M, et al. (2005). "mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR". J. Mol. Endocrinol. 32 (2): 339–48. doi:10.1677/jme.0.0320339. PMID 15072543.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Herringa RJ, Roseboom PH, Kalin NH (2006). "Decreased amygdala CRF-binding protein mRNA in post-mortem tissue from male but not female bipolar and schizophrenic subjects". Neuropsychopharmacology. 31 (8): 1822–31. doi:10.1038/sj.npp.1301038. PMID 16482088.