Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.[5][6][7]

CREB5
Identifiers
AliasesCREB5, CRE-BPA, CREB-5, cAMP responsive element binding protein 5, CREBPA
External IDsOMIM: 618262; MGI: 2443973; HomoloGene: 18215; GeneCards: CREB5; OMA:CREB5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001011666
NM_004904
NM_182898
NM_182899

NM_172728
NM_001327821

RefSeq (protein)

NP_001011666
NP_004895
NP_878901
NP_878902

NP_001314750
NP_766316

Location (UCSC)Chr 7: 28.3 – 28.83 MbChr 6: 53.26 – 53.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1,[8] and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146592Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053007Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S (Oct 1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA". Oncogene. 8 (10): 2749–58. PMID 8378084.
  6. ^ Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (Mar 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J Biol Chem. 268 (6): 4259–66. doi:10.1016/S0021-9258(18)53604-8. PMID 8440710.
  7. ^ a b "Entrez Gene: CREB5 cAMP responsive element binding protein 5".
  8. ^ Cumulated Index Medicus. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine. 1993.
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Further reading

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