CLEC2D

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.

CLEC2D
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4QKG, 4QKH, 4QKI, 4QKJ, 4WCO
Identifiers
Aliases	CLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDs	OMIM: 605659 HomoloGene: 137257 GeneCards: CLEC2D
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 9,664,969 bp End 9,699,553 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon spleen lymph node blood appendix right uterine tube monocyte bone marrow cells tibial nerve gastric mucosa n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane signaling receptor activity carbohydrate binding protein binding Cellular component plasma membrane membrane integral component of membrane endoplasmic reticulum integral component of plasma membrane cell surface Biological process regulation of immune response cell surface receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29121 n/a Ensembl ENSG00000069493 n/a UniProt Q9UHP7 n/a RefSeq (mRNA) NM_001004419 NM_001004420 NM_001197317 NM_001197318 NM_001197319 NM_013269 n/a RefSeq (protein) NP_001004419 NP_001184246 NP_001184247 NP_001184248 NP_037401 n/a Location (UCSC) Chr 12: 9.66 – 9.7 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined. CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

Further reading

• Boles KS, Barten R, Kumaresan PR, et al. (1999). "Cloning of a new lectin-like receptor expressed on human NK cells". Immunogenetics. 50 (1–2): 1–7. doi:10.1007/s002510050679. PMID 10541800. S2CID 30994521.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors". Nat. Immunol. 4 (8): 801–7. doi:10.1038/ni954. PMID 12858173. S2CID 23775959.
• Hu YS, Zhou H, Myers D, et al. (2004). "Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts". J. Bone Miner. Res. 19 (1): 89–99. doi:10.1359/JBMR.0301215. PMID 14753741. S2CID 28328386.
• Carlyle JR, Jamieson AM, Gasser S, et al. (2004). "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3527–32. Bibcode:2004PNAS..101.3527C. doi:10.1073/pnas.0308304101. PMC 373496. PMID 14990792.
• Mathew PA, Chuang SS, Vaidya SV, et al. (2004). "The LLT1 receptor induces IFN-gamma production by human natural killer cells". Mol. Immunol. 40 (16): 1157–63. doi:10.1016/j.molimm.2003.11.024. PMID 15104121.
• Gange CT, Quinn JM, Zhou H, et al. (2004). "Characterization of sugar binding by osteoclast inhibitory lectin". J. Biol. Chem. 279 (28): 29043–9. doi:10.1074/jbc.M312518200. PMID 15123656.
• Aldemir H, Prod'homme V, Dumaurier MJ, et al. (2006). "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor". J. Immunol. 175 (12): 7791–5. doi:10.4049/jimmunol.175.12.7791. PMID 16339512.
• Rosen DB, Bettadapura J, Alsharifi M, et al. (2006). "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor". J. Immunol. 175 (12): 7796–9. doi:10.4049/jimmunol.175.12.7796. PMID 16339513.
• Rosen DB, Cao W, et al. (2008). "Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells". J. Immunol. 180 (10): 6508–6517. doi:10.4049/jimmunol.180.10.6508. PMC 2577150. PMID 18453569.

External links

• Human CLEC2D genome location and CLEC2D gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9UHP7 (Human C-type lectin domain family 2 member D) at the PDBe-KB.